Single-player games like Vaccine
Below are 11 single-player Steam games similar to Vaccine, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Vaccine page.
Ranked picks
- 1
Unstable Nuclear Reactor
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
An incremental hex-puzzle roguelite game where merging atomic elements prevents a nuclear meltdown.
- 2
Crowntakers
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Crowntakers combines turn-based strategy with RPG elements and takes you at the behest of the crown into a medieval fantasy world full of challenging encounters and epic adventures. With its randomly generated world, Crowntakers offers a varied gaming experience every time you set out to fight evil.
- 3
Invisible, Inc.
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Take control of Invisible's agents in the field and infiltrate the world's most dangerous corporations. Stealth, precision, and teamwork are essential in high-stakes, high-profit missions, where every move may cost an agent their life.
- 4
HyperRogue
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Indie with Vaccine.
Time moves when you move in a truly non-Euclidean world
- 5
NEO Scavenger
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
NEO Scavenger is a game where you must survive in the wasteland long enough to figure out who you are. Each turn, you must decide where to go, how to scavenge for supplies, and how to deal with anything and anyone you encounter.
- 6
FTL: Faster Than Light
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
This "spaceship simulation roguelike-like" allows you to take your ship and crew on an adventure through a randomly generated galaxy filled with glory and bitter defeat.
- 7
Wildfrost
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Take on the elements in Wildfrost, a tactical roguelike deckbuilder! Journey across a frozen tundra, collecting cards strong enough to banish the eternal winter…
- 8
Insurmountable
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Confront various terrains as a lonely mountaineer and endure the countless dangers of climbing! Many tough decisions await you in a risky environment. Make your way up and down the mountain, overcoming insurmountable heights!
- 9
Warpaint
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
It's chess with catapults! Warpaint is a casual tabletop wargame where you command an army of dwarves and catapults. You can paint your army with pixel perfect control, just like real miniatures! Victory is won through superior tactical positioning and siege dexterity.
- 10
Space Viking Raiders
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Co-op action role-playing comedy in a sci-fi multiverse. 3-5 hour campaign, 1-4 players online! Badass abilities will have you wreck havoc with physics and mass destruction. The best vikings use their limited energy to efficiently wipe out hordes of enemies. PvE MOBA-style hack-and-cast!
- 11
Space Viking Raiders VR
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Looking for an online co-op game to play through with friends? You want a hilarious story with full voice acting! Diablo meets Gauntlet in this dungeon crawler action RPG. Wreck havoc with physics and mass destruction in SPACE VIKING RAIDERS! Wishlist now!