Single-player games like Vaccine
Below are 11 single-player Steam games similar to Vaccine, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Vaccine page.
Ranked picks
- 1
Unstable Nuclear Reactor
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
An incremental hex-puzzle roguelite game where you merge atoms into higher elements, trigger massive chain combos, earn radioactive coins, and manage your ring capacity to survive as long as possible.
- 2
Reflect
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
This is a simple and complex puzzle game about light. You need to use Optical components to direct lights and lit up the rings.
- 3
Herman Electro
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Dungeon crawling roguelike where rooms contain puzzles, not enemies. Discover alternative solutions which use up different tools. Manage you resources, spend rare tools, and discover secrets. Will your covert broadcasts be answered? 480+ Puzzles.
- 4
Crowntakers
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Crowntakers combines turn-based strategy with RPG elements and takes you at the behest of the crown into a medieval fantasy world full of challenging encounters and epic adventures. With its randomly generated world, Crowntakers offers a varied gaming experience every time you set out to fight evil.
- 5
Invisible, Inc.
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Take control of Invisible's agents in the field and infiltrate the world's most dangerous corporations. Stealth, precision, and teamwork are essential in high-stakes, high-profit missions, where every move may cost an agent their life.
- 6
HyperRogue
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Indie with Vaccine.
Time moves when you move in a truly non-Euclidean world
- 7
Wildfrost
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Take on the elements in Wildfrost, a tactical roguelike deckbuilder! Journey across a frozen tundra, collecting cards strong enough to banish the eternal winter…
- 8
Quest of Dungeons
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Indie with Vaccine.
Quest of Dungeons is a turn based dungeon crawler game featuring a good old 16-bit retro artistic look. By playing as either a Warrior, Wizard, Assassin or Shaman you have to traverse dungeons, defeat enemies and loot everything you can in order to survive.
- 9
Warpaint
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
It's chess with catapults! Warpaint is a casual tabletop wargame where you command an army of dwarves and catapults. You can paint your army with pixel perfect control, just like real miniatures! Victory is won through superior tactical positioning and siege dexterity.
- 10
Space Viking Raiders
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Co-op action role-playing comedy in a sci-fi multiverse. 3-5 hour campaign, 1-4 players online! Badass abilities will have you wreck havoc with physics and mass destruction. The best vikings use their limited energy to efficiently wipe out hordes of enemies. PvE MOBA-style hack-and-cast!
- 11
Space Viking Raiders VR
Single-player alternative to Vaccine — playable solo, no multiplayer required. Shares Strategy and Indie with Vaccine.
Looking for an online co-op game to play through with friends? You want a hilarious story with full voice acting! Diablo meets Gauntlet in this dungeon crawler action RPG. Wreck havoc with physics and mass destruction in SPACE VIKING RAIDERS! Wishlist now!