Single-player games like Slime mutation
Below are 8 single-player Steam games similar to Slime mutation, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Slime mutation page.
Ranked picks
- 1

Dungeon and Gravestone
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Steel yourself in the face of insurmountable opposition as you traverse this ever-changing world in a bid to save it from imminent desolation.
- 2

Diary of Lucie
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Diary of Lucie is action-roguelite game made with RPG Maker. In addition to simply avoiding the enemy's barrage, strategically use the enemy's bullet to make the battle situation advantageous!
- 3

Himno - The Silent Melody
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Himno - The Silent Melody is an atmospheric roguelite action RPG. Explore different interconnected environments, gather materials to create your unique arsenal and build and automate your base.
- 4

Dungeon Survivors
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Dungeon Survivors is a top-down fantasy roguelite where you can use your class abilities to fight off a horde of fantasy monsters. Choose from a variety of abilities and items to create unique builds and survive with 1-4 players.
- 5

Devious Dungeon
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Set in the Dark Ages, Devious Dungeon is a medieval focused action platformer with RPG styled upgrades.
- 6

Rogue Legacy
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Rogue Legacy is a genealogical rogue-"LITE" where anyone can be a hero. Each time you die, your child will succeed you. Every child is unique. One child might be colorblind, another might be a dwarf with vertigo. But that's OK, because no one is perfect, and you don't have to be to succeed.
- 7

Dungeon Souls
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Dungeon Souls is an action-adventure roguelike dungeon crawler which draws heavy inspiration from Nuclear Throne, Risk of Rain, and Overture. Explore vast procedurally generated dungeons, collect loot, and slay hordes of challenging enemies!
- 8

Legend of Dungeon
Single-player alternative to Slime mutation — playable solo, no multiplayer required. Shares Action and Indie with Slime mutation.
Legend of Dungeon is a randomly generated action RPG Beat'em'up with heavy Rogue-like elements, striking visuals, and dynamic music.