Single-player games like Xenomycology
Below are 8 single-player Steam games similar to Xenomycology, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Xenomycology page.
Ranked picks
- 1
Frontier Control : Invasion
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy with Xenomycology.
Frontier Control: Invasion is a Real-Time Strategy survival game in which you play the commander of a human space colony under the attack of outer space robots. Build your base, train your colony, and fight herds of enemies and bosses.
- 2
Cosmic Robots
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Simulation with Xenomycology.
Defend your planet from waves of robot invaders! Build powerful turrets, upgrade your defenses, and command robot units to fight drones, tanks, and massive bosses. Then send your own forces to attack the enemy planet in this action-packed sci-fi tower defense game.
- 3
Diffusion
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.
- 4
Stelvyr: Colony Defense
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
Build and defend a space colony where every unit of power and every crew assignment matters. Expand production, research new technologies, shape the battlefield with walls and weapons, and adapt your strategy against alien swarms across nine campaign operations.
- 5
Parallax Blue
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
A strategy tower defence where you create the towers! Gather resources, build towers, defeat bugs, and survive. Unlock new weapons, create towers, gather resources, and die. Don't fall short of the Company's expectations... these resources are worth more than any life, including yours.
- 6
The Rift Tower Defense
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
The Rift is a tower defense game with elements of RPG gameplay that will appeal to players of all skill levels. Enemies from an alternate universe are attacking and it's up to the player to stop them by strategically building defensive towers.
- 7
Raging Titan
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
Build your towers, plan your efforts, watch out for changing paths and strike back against the alien invaders in this challenging tower defense game!
- 8
CARNAGE OFFERING Tower Defense
Single-player alternative to Xenomycology — playable solo, no multiplayer required. Shares Strategy and Indie with Xenomycology.
The replicator robots are back! It's 2528. The machines are increasingly infecting the planets with genetically modified monsters. Challenge them and try to stop the onslaught. Upgrade buildings and heroes, mine resources, discover technology and fight to save humanity!