IMHO.

Single-player games like Bioguard

Below are 8 single-player Steam games similar to Bioguard, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.

Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Bioguard page.

Ranked picks

  1. 1
    The Territory of Egg 2 — Steam game cover

    The Territory of Egg 2

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    The Territory of Egg 2 is an unique tower defense indie game. Place Egg Towers, choose evolution branches, combine skills and build defenses. The souls of Heroic Eggs await your awakening! Explore and gather resources in the dark forest, unlock the technology tree, and defeat even stronger enemies!

    2024StrategyIndie0.74 USDSingle-playerSimilar games →
  2. 2
    Laser Defense Extreme — Steam game cover

    Laser Defense Extreme

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    Laser Defense Extreme is a Tower Defense Game, with a Killstreak System. Place your "Towers" strategically and eliminate the incoming enemies.

    2024StrategyIndie0.99 USDSingle-playerSimilar games →
  3. 3
    Dead Soul TowerDefense:Shadow Labyrinth — Steam game cover

    Dead Soul TowerDefense:Shadow Labyrinth

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    This is a pixel-style classic tower defense game. You need to summon souls to fend off enemy attacks, and each type of soul has its unique skill tree. You can also build your own maze in the game to prevent enemy invasions.

    2025StrategyIndie9.99 USDSingle-playerSimilar games →
  4. 4
    Micron Defense Force — Steam game cover

    Micron Defense Force

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy with Bioguard.

    A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

    2024Strategy9.99 USDSingle-playerSimilar games →
  5. 5
    Siegebreaker — Steam game cover

    Siegebreaker

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy with Bioguard.

    Conquer the realm in this strategic tower defense game. Build unique towers, unlock powerful upgrades, and master new tactics to overpower your enemies and vanquish the fallen gods.

    2024Strategy11.99 USDDeck PlayableSingle-playerSimilar games →
  6. 6
    Creeping Dusk — Steam game cover

    Creeping Dusk

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    Creeping Dusk is a tower defense game. Build a town around an abandoned gold mine and defend against monsters that swarm the area. Fortify your defenses, and prepare for the increasingly challenging nights. Will you be able to protect your town from the encroaching darkness?

    2024StrategyIndie5.99 USDDeck PlayableSingle-playerSimilar games →
  7. 7
    Dungeon Warfare — Steam game cover

    Dungeon Warfare

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    Dungeon Warfare is a challenging tower defense strategy game where you become a dungeon lord to defend your dungeons with deadliest of traps and insidious contraptions against greedy adventurers and wanna-be heroes.

    2015StrategyIndie9.99 USDSingle-playerSimilar games →
  8. 8
    Nordhold — Steam game cover

    Nordhold

    Single-player alternative to Bioguard — playable solo, no multiplayer required. Shares Strategy and Indie with Bioguard.

    Enemies are coming! Every decision matters: build your city, grow the economy, and prepare for enemy waves. Strengthen your defenses, adapt your strategy, and unleash your hero’s full potential. This unique Tower Defense will test your skills – are you worthy to claim a place at Valhalla?

    2025StrategyIndie19.99 USDDeck PlayableSingle-playerSimilar games →