Single-player games like Mutation
Below are 8 single-player Steam games similar to Mutation, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Mutation page.
Ranked picks
- 1

Eldritch
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Indie with Mutation.
Eldritch is the original imsim roguelike: a first-person action game inspired by roguelikes, immersive sims, and H. P. Lovecraft.
- 2

Deus Ex: The Fall
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Adventure with Mutation.
Deus Ex: The Fall is set in 2027– a golden era for science, technology and human augmentation, but also a time of great social divide and global conspiracy. Powerful corporations have seized control from governments and command the drug supply needed by augmented humans to survive.
- 3

Dying Light
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and RPG with Mutation.
First-person action survival game set in a post-apocalyptic open world overrun by flesh-hungry zombies. Roam a city devastated by a mysterious virus epidemic. Scavenge for supplies, craft weapons, and face hordes of the infected.
- 4

Mortal Frame: Reforged in Survival
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Indie with Mutation.
"Mortal Frame" is a sci-fi RPG combining open-world exploration and sandbox survival. The player explores a challenging world, gathers resources, crafts gear, captures AI companions, and upgrades modification chips to enhance their abilities, facing powerful foes and uncovering hidden mysteries.
- 5

The Last Dive
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Indie with Mutation.
A tense and tactical FPS with roguelite progression. Descend level by level through dangerous, shifting environments. Brutal, slow-paced combat where every shot counts. Find the elevator. Go deeper into the Void. Until it’s your last dive.
- 6

Welcome to Basingstoke
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Indie with Mutation.
Basingstoke is a tense rogue-like that mixes stealth and arcade action. Explore the smouldering ruins of Basingstoke, a world of reanimated undead and ferocious alien monsters. Scavenge as you go, crafting equipment to help you in your mission: escape Basingstoke!
- 7

DESOLATE
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Adventure with Mutation.
DESOLATE is a first person horror survival experience. Form a research team with up to 4 players and explore an open world filled with mysteries and unsolved questions, or do it all on your own.
- 8

Tunguska: The Visitation - Final Cut
Single-player alternative to Mutation — playable solo, no multiplayer required. Shares Action and Indie with Mutation.
Tunguska: The Visitation is a single player top-down shooter RPG. Seek fortune as a Ghoul Hunter in an abandoned Soviet Exclusion Zone. Use your grit and ingenuity to survive deadly radiation, mysterious anomalies, and poisonous mutants. Go in guns-blazing, or stay in the shadows - your choice.