IMHO.

Single-player games like SynthetiCell BioClicker

Below are 9 single-player Steam games similar to SynthetiCell BioClicker, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.

Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like SynthetiCell BioClicker page.

Ranked picks

  1. 1
    Mining Factory — Steam game cover

    Mining Factory

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Can mine, can fight, and has sisters, collecting more than 30 types of ore such as iron ore, copper ore, manganese ore, chrome ore, vanadium ore, titanium ore, etc. Team up to break through the 100th floor

    2022StrategyIndieSimulation4.99 USDSingle-playerSimilar games →
  2. 2
    Mining Copper — Steam game cover

    Mining Copper

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Collect copper ore and pass through various smelting equipment to produce copper plates.

    2022StrategyIndieSimulation3.99 USDSingle-playerSimilar games →
  3. 3
    Gold Rush Clicker — Steam game cover

    Gold Rush Clicker

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Dive into "Gold Rush Clicker," an idle clicker game where you start as a novice miner. Tap to mine gold, buy upgrades, and face strategic challenges. With procedurally generated levels, stunning graphics, and Steam achievements, it's an endless journey to become the ultimate mining tycoon!

    2023StrategyIndieAdventure1.99 USDDeck PlayableSingle-playerSimilar games →
  4. 4
    Fracture Field — Steam game cover

    Fracture Field

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Indie and Simulation with SynthetiCell BioClicker.

    Fracture Field is an idle/incremental quarry mining game. Shatter rocks with timed swings then invest your earnings into upgrades. Build a fleet of drones to automate your empire, bomb tough layers, and unlock powerful prestige upgrades on your journey to master the quarry.

    2026IndieSimulationCasual6.99 USDDeck PlayableSingle-playerSimilar games →
  5. 5
    Idle Grid — Steam game cover

    Idle Grid

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Build and optimize your industrial empire in this grid-based idle game. Place factories, power plants, and research labs strategically to maximize efficiency through adjacency bonuses. Upgrade your buildings, manage power consumption, and watch your profits soar while you're away.

    2025ActionStrategyIndieFreeSingle-playerSimilar games →
  6. 6
    Moose Miners — Steam game cover

    Moose Miners

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Take control of a mining operation run by moose. They mine and sell the gems. You need to decide where to spend the profits. Hire more miners and upgrade their gear. Buy new rails and minecarts to get deeper into the mine. The deeper you get the more valuable gems you will find.

    2024StrategyIndieSimulation9.99 USDDeck PlayableSingle-playerSimilar games →
  7. 7
    Incremental Town RPG — Steam game cover

    Incremental Town RPG

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Strategy and Indie with SynthetiCell BioClicker.

    Incremental Town RPG lets you build and manage a thriving village. Master resource management, develop a robust economy, and enjoy a relaxing experience as you equip your settlement to conquer new lands and challenges!

    2024StrategyIndieSimulation3.99 USDDeck PlayableSingle-playerSimilar games →
  8. 8
    Factory Town Idle — Steam game cover

    Factory Town Idle

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Indie and Simulation with SynthetiCell BioClicker.

    An entire town builder experience packed into a living spreadsheet. Build housing, assign workers, then craft and sell a huge variety of items to level up your town and expand your civilization across the world!

    2024IndieSimulationCasual4.99 USDDeck PlayableSingle-playerSimilar games →
  9. 9
    Xtreme Club Racing — Steam game cover

    Xtreme Club Racing

    Single-player alternative to SynthetiCell BioClicker — playable solo, no multiplayer required. Shares Indie with SynthetiCell BioClicker.

    Get behind the wheel in one of the most frenetic extreme driving games. Various interactive elements such as hurricanes, lava balls, giant spinning tops, which will cross in the middle of the competition track and will put your reflexes and extreme driving to the limit.

    2024SportsIndieRacing6.99 USDSingle-playerSimilar games →