IMHO.

Games like Supre-Immune

If Supre-Immune is your kind of game, the closest matches are Arms of God, Genome Guardian 2 and Mighty X Arms — picked from the ranked list below. Each pick is ranked by what players of this game also play, shared genres and tags, and review-mined similarity — not a generic popularity list.

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About Supre-Immune: Join a roguelike action where cute immune cells battle viruses. Collect data in fast-paced combat, gain weapons and abilities through evolution, or level up to grow stronger. The fun of building your own super immune cell with different combinations each run is up to you!

2025ActionStrategyIndieCasualEarly Access6.99 USDWindowsby Indion
Supre-Immune — Steam game cover

Players who liked Supre-Immune also play

Steam players who put hours into Supre-Immune also tend to own these titles — a signal called collaborative filtering. imho.run cross-references millions of library ownership patterns to surface games whose real audiences overlap, regardless of whether their genre tags match.

  1. Arms of God

    WHY THIS

    Top pick for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    Gear up for a battle through hell in this roguelite Bullet Heaven Arena Autoshooter with Doom-inspired gore vibes, metal music, and a satisfying combat feel. Wield five weapons at once, upgrade and merge them to forge indestructible builds, and bring divine justice to a world on the brink of chaos.

    2026ActionIndieRPG9.77 USDSteam ↗
  2. Genome Guardian 2

    WHY THIS

    Second-strongest match for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!

    2026ActionIndieRPG15.99 USDDeck PlayableSteam ↗
  3. Mighty X Arms

    WHY THIS

    Third-strongest match for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    Mighty X Arms is a roguelike survivor inspired by Brotato, featuring collectible weapon-creatures called Arms. Build your loadout, upgrade them, and mow down enemy swarms to survive.

    2026ActionIndieRPGSteam ↗
  4. Compadrone: Land Wars

    WHY THIS

    Ranked #4 for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.

    2025ActionIndieAdventure4.99 USDSteam ↗
  5. Deck of Potential

    WHY THIS

    Ranked #5 for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Strategy with Supre-Immune.

    Deck of Potential combines roguelike deckbuilder with bullet heaven. Collect cards, fuse them, and slap on sticker upgrades to beat thousands of monsters. Take down dungeon bosses, unlock new cards, characters, and discover fusion recipes to build the ultimate auto-firing deck.

    2026ActionStrategyIndieSteam ↗
  6. Bug Drop

    WHY THIS

    Ranked #6 for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    Fight, upgrade, and survive in a fast-paced top-down action roguelite where 20 unique heroes with special traits, weapons and abilities take on the swarm of alien bugs.

    2026ActionIndieSteam ↗
  7. Hover Point

    WHY THIS

    Ranked #7 for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Supre-Immune.

    Hover Point is a physics-based rogue-lite bullet hell where movement is your weapon. Dodge chaotic swarms with auto-fire action, build your skill tree, and climb global leaderboards. Master the chaos solo or in co-op via mouse-only, keyboard-only, or controller-only playstyles.

    2026ActionIndieCasual4.99 USDSteam ↗
  8. Lost Galaxy: Survivors

    WHY THIS

    Ranked #8 for Supre-Immune fans by collaborative filtering across millions of Steam libraries. Shares Action and Strategy with Supre-Immune.

    Defend massive interdimensional portals against relentless alien swarms in this fast-paced sci-fi top-down survival shooter.

    ActionStrategyCasualSteam ↗

Cheaper alternatives

Games in the same vein priced at least 40% below Supre-Immune at current Steam store prices.

  1. POSTAL 2

    WHY THIS

    Priced ~86% under Supre-Immune on Steam right now. Shares Action and Indie with Supre-Immune.

    Live a week in the life of "The POSTAL Dude"; a hapless everyman just trying to check off some chores. Buying milk, returning an overdue library book, getting Gary Coleman's autograph, what could possibly go wrong?

    2012ActionIndieAdventure0.99 USDDeck VerifiedSteam ↗
  2. Buckshot Roulette

    WHY THIS

    Priced ~57% under Supre-Immune on Steam right now. Shares Action and Indie with Supre-Immune.

    Play Russian roulette with a 12-gauge shotgun. Four enter. One leaves. Roll the dice with your life. Good luck!

    2024ActionIndieSimulation2.99 USDDeck PlayableSteam ↗
  3. GRIS

    WHY THIS

    Priced ~46% under Supre-Immune on Steam right now. Shares Indie with Supre-Immune.

    Gris is a hopeful young girl lost in her own world, dealing with a painful experience in her life. Her journey through sorrow is manifested in her dress, which grants new abilities to better navigate her faded reality.

    2018IndieAdventure3.74 USDDeck VerifiedSteam ↗
  4. The Test

    WHY THIS

    Priced ~72% under Supre-Immune on Steam right now. Shares Indie with Supre-Immune.

    You will answer a series of questions that will reveal truths from deep within. These questions may make you uncomfortable, but with great knowledge comes great sacrifice. Can you make it all the way through The Test, and if you do, are you sure you want the answers you seek?

    2020IndieAdventureSimulation1.99 USDDeck VerifiedSteam ↗
  5. Milk inside a bag of milk inside a bag of milk

    WHY THIS

    Priced ~79% under Supre-Immune on Steam right now. Shares Indie with Supre-Immune.

    A short story about what sort of challenges everyday little things can be. Help the girl buy milk, be the first not to disappoint her.

    2020IndieAdventure1.49 USDDeck PlayableSteam ↗
  6. Blood and Bacon

    WHY THIS

    Priced ~86% under Supre-Immune on Steam right now. Shares Action and Casual with Supre-Immune.

    This Co-op Shooter , has Day and Night levels, multiple maps, players will take on 25 enemy types and numerous bosses, like Gargantuan Monsters and Minibosses every 10 days as you explore, shoot and run for your life against the onslaught of porcine monstrosities.

    2016ActionAdventureCasual0.99 USDSteam ↗
  7. Crypt of the NecroDancer

    WHY THIS

    Priced ~57% under Supre-Immune on Steam right now. Shares Action and Indie with Supre-Immune.

    Crypt of the NecroDancer is an award winning hardcore roguelike rhythm game. Move to the music and deliver beatdowns to the beat! Groove to the epic Danny Baranowsky soundtrack, or select songs from your own MP3 collection!

    2015ActionIndieRPG2.99 USDDeck VerifiedSteam ↗
  8. A Short Hike

    WHY THIS

    Priced ~43% under Supre-Immune on Steam right now. Shares Indie with Supre-Immune.

    Hike, climb, and soar through the peaceful mountainside landscapes of Hawk Peak Provincial Park as you make your way to the summit.

    2019IndieAdventure3.99 USDDeck VerifiedSteam ↗

Free alternatives

Free-to-play games that recommended players of this title also tend to enjoy.

  1. Doki Doki Literature Club!

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie and Casual with Supre-Immune.

    The Literature Club is full of cute girls! Will you write the way into their heart? This game is not suitable for children or those who are easily disturbed.

    2017IndieFree To PlayCasualFreeDeck PlayableSteam ↗
  2. Life is Strange - Episode 1

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action with Supre-Immune.

    Episode 1 now FREE! Life is Strange is an award-winning and critically acclaimed episodic adventure game that allows the player to rewind time and affect the past, present and future.

    2015ActionAdventureFreeDeck PlayableSteam ↗
  3. Helltaker

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie with Supre-Immune.

    Helltaker is a short game about sharply dressed demon girls.

    2020IndieAdventureFree To PlayFreeDeck PlayableSteam ↗
  4. Ultimate Custom Night

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Supre-Immune.

    Welcome to the ultimate FNAF mashup, featuring 50 selectable characters and custom difficulties!

    2018ActionIndieFree To PlayFreeSteam ↗
  5. Bongo Cat

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie with Supre-Immune.

    Bongo cat needs your help. Bongo cat needz more hatz!!! Every time you press a key, Bongo cat will punch your taskbar. Type, click, play, work to collect more points. Which hats will you find?

    2025IndieSimulationMassively MultiplayerFreeDeck PlayableSteam ↗
  6. The Murder of Sonic the Hedgehog

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie and Casual with Supre-Immune.

    Sonic the Hedgehog...was murdered!? Get to the bottom of the mystery in this brand-new adventure!

    2023IndieSimulationFree To PlayFreeDeck PlayableSteam ↗
  7. Indigo Park: Chapter 1

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Supre-Immune.

    Explore the abandoned childhood wonder of Indigo Park! Guided by Rambley the Raccoon, help restore power to the destroyed amusement park while you run from the reason it shut down.

    2024ActionIndieAdventureFreeDeck PlayableSteam ↗
  8. STRAFTAT

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action with Supre-Immune.

    STRAFTAT is a 1v1/2v2 ONLINE first person SHOOTER with quick rounds in over 350 MAPS ; Including all WEAPONS, proximity chat and 4 players FFA.

    2024ActionFreeDeck PlayableSteam ↗

Frequently asked about Supre-Immune

How much does Supre-Immune cost?
Supre-Immune is listed on Steam at 6.99 USD (current store price; Steam sales may reduce this temporarily).
What games are most similar to Supre-Immune?
Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Supre-Immune are Arms of God, Genome Guardian 2, Mighty X Arms.
Who developed Supre-Immune?
Supre-Immune was developed by Indion and published by Indion, Imperfect Games.

imho.run ranks Steam game alternatives using a mix of collaborative filtering (ALS / iALS / EASE / LightGCN), content scoring over genres, categories, Steam tags, developers, and publishers, plus AI-extracted vibes mined from review text. The page above is generated in seed mode anchored on Supre-Immune.

For library-aware picks tuned to your specific taste, sign in with Steam on the home page.