IMHO.

Single-player games like Natural Selection University

Below are 8 single-player Steam games similar to Natural Selection University, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.

Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Natural Selection University page.

Ranked picks

  1. 1
    Astral Throne — Steam game cover

    Astral Throne

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    Uncover the mystery of a land beset by a Falling Star's curse in this Roguelike Strategy RPG inspired by the classics. Build your party, recruit new allies, and synergize your team's skills for decisive victory.

    2025StrategyIndieRPG19.99 USDDeck PlayableSingle-playerSimilar games →
  2. 2
    Inkbound — Steam game cover

    Inkbound

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    A turn-based tactical roguelike from the creators of Monster Train. Play solo or co-op, create powerful builds, and save the Atheneum.

    2024ActionStrategyIndie8.99 USDDeck PlayableSingle-playerSimilar games →
  3. 3
    The Storm Guard: Darkness is Coming — Steam game cover

    The Storm Guard: Darkness is Coming

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    The Storm Guard is a challenging turn-based roguelike role-playing game inspired by the Night’s Watch in the Game of Thrones. You assume the role of the Lord Commander of the Storm Guard leading the order during difficult times. An ancient dragon and its minions have returned, threatening the realm of men.

    2016ActionStrategyIndie19.99 USDSingle-playerSimilar games →
  4. 4
    Black Book — Steam game cover

    Black Book

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    “Black Book” is a dark RPG Adventure, based on Slavic myths, in which you play as a young sorceress. Fight evil forces in card-based battles and explore the world, where humans live alongside mythological creatures.

    2021StrategyIndieAdventure24.99 USDDeck PlayableSingle-playerSimilar games →
  5. 5
    Heroes of Steel RPG — Steam game cover

    Heroes of Steel RPG

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    Heroes of Steel is a tactical RPG set in a grim post-apocalyptic fantasy world. Coordinate your party of four heroes in turn-based combat and navigate a engaging world and story.

    2014StrategyIndieRPG9.99 USDSingle-playerSimilar games →
  6. 6
    Forgotten Mines — Steam game cover

    Forgotten Mines

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and RPG with Natural Selection University.

    Wreak vengeance and retake lost mines from goblins, orcs, skeletons, and demons in this small-scale tactical roguelite RPG. Build the perfect expedition team and turn the underworld red with each challenging, fast-paced run.

    2024StrategyRPG7.99 USDSingle-playerSimilar games →
  7. 7
    The Last Spell — Steam game cover

    The Last Spell

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    Defend the last bastion of humanity with your squad of heroes! Exterminate fiendish monsters with magic and brute force by night and re-build your battered city defenses by day in this tactical RPG with rogue-lite mechanics.

    2023ActionStrategyIndie24.99 USDDeck VerifiedSingle-playerSimilar games →
  8. 8
    Touhou: Lost Branch of Legend — Steam game cover

    Touhou: Lost Branch of Legend

    Single-player alternative to Natural Selection University — playable solo, no multiplayer required. Shares Strategy and Indie with Natural Selection University.

    Welcome to Eientei, combine multiple colors of mana to build your ideal deck, duel with gensokyo girls, and chase back the mysterious moon treasure. Also, enjoy the unpredictable Roguelike with fantasy Danmaku!

    2022StrategyIndieAdventure23.99 USDDeck PlayableSingle-playerSimilar games →