Single-player games like Mad Experiments: Escape Room - Sanctuary
Below are 9 single-player Steam games similar to Mad Experiments: Escape Room - Sanctuary, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Mad Experiments: Escape Room - Sanctuary page.
Ranked picks
- 1

Mad Experiments: Escape Room
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Strategy and Indie with Mad Experiments: Escape Room - Sanctuary.
Award-nominated escape game. Alone or with up to 5 players, explore 3 unique rooms, solve mind-bending puzzles, and unravel the dark secrets of the Professor Cheshire and his experiments.
- 2

The Lost Castle: Escape Room
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Strategy and Indie with Mad Experiments: Escape Room - Sanctuary.
Medieval Escape Room with Online Co-op. Wake up in a jail cell of a long-forgotten castle filled with mysteries and mind-braking puzzles. Seven rooms to challenge yourself with the mysteries of the lost castle before the timer runs out!
- 3

Realms of Riddles: Wizards'Keep
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Indie and Adventure with Mad Experiments: Escape Room - Sanctuary.
Explore a magical castle in this first-person puzzle adventure. Solve puzzles across worlds connected by portals, recover your lost memories, and uncover what happened to the kingdom.
- 4

Jangan Tersesat
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Strategy and Indie with Mad Experiments: Escape Room - Sanctuary.
"Jangan Tersesat" is a single-location, puzzle-based psychological horror game you can complete in about 1-2 hours. Explore an old dormitory full of mystery, solve its secrets, evade what hunts you in the dark, and decide whether you will survive... or become part of its story.
- 5

Mad Experiments: Escape Room 2
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Adventure and Simulation with Mad Experiments: Escape Room - Sanctuary.
Mad Experiments 2: Escape Room is the sequel of the award-nominated multiplayer escape game Mad Experiments. Alone or with up to 5 friends, follow the story of Hildegarde and Professor Cheshire, explore rich environments to find clues, and solve mind-bending puzzles to escape!
- 6

Escape Simulator 2
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Indie and Adventure with Mad Experiments: Escape Room - Sanctuary.
Sequel to the best-selling escape room game, brings a fresh take on first-person puzzles with a variety of new rooms to explore solo or with friends. Solve intricate puzzles, uncover hidden secrets, or craft your own escape rooms with Room Editor 2.0.
- 7

First Class Escape: The Train of Thought
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Indie and Adventure with Mad Experiments: Escape Room - Sanctuary.
"First Class Escape: The Train of Thought" is a co-operative atmospheric escape room puzzle game, set in a beautifully realized vintage train. Do you think you have what it takes to solve the puzzles and escape the train?
- 8

Escape Memoirs: Mansion Heist
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Indie and Adventure with Mad Experiments: Escape Room - Sanctuary.
"Escape Memoirs: Mansion Heist" is a co-operative atmospheric reverse escape-room puzzle game. You are a master thief who has been hired to rob a mysterious mansion, filled with various puzzles. Do you think you have what it takes to conquer the challenges that await you in the mansion.
- 9

Puropu Defense Squad
Single-player alternative to Mad Experiments: Escape Room - Sanctuary — playable solo, no multiplayer required. Shares Strategy and Indie with Mad Experiments: Escape Room - Sanctuary.
Defend your world as sentient Props in Puropu Defense Squad! Build, upgrade, and evolve your heroes to crush waves of filthy humans worldwide. Dive into a unique mix of third-person action and tower defense—solo or with friends—in an endlessly replayable co-op campaign!