Single-player games like Mutagenic 2
Below are 9 single-player Steam games similar to Mutagenic 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Mutagenic 2 page.
Ranked picks
- 1

Veil Walker
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and RPG with Mutagenic 2.
Veil Walker is an ARPG, where a rift between realms has fractured the veil of reality, spilling forth a malevolent force that corrupts all it touches. As a Veil Walker you hunt down any corrupted, either alone or with others, while at the same time building up your own skills and abilities.
- 2

Nioh 3
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and RPG with Mutagenic 2.
In the third game in the dark samurai action RPG series Nioh, you will need to use both Samurai and Ninja combat styles in your battles against formidable yokai as you explore a thrilling open field.
- 3

Wo Long: Fallen Dynasty
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and RPG with Mutagenic 2.
A new dark fantasy Three Kingdoms action RPG from Team NINJA, the developers of Nioh.
- 4

Path of Exile
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and Indie with Mutagenic 2.
You are an Exile, struggling to survive on the dark continent of Wraeclast, as you fight to earn power that will allow you to exact your revenge against those who wronged you. Path of Exile is an online Action RPG set in a dark fantasy world. The game is completely free and will never be pay-to-win.
- 5

Dinoblade
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and Indie with Mutagenic 2.
Dinoblade is an intense action RPG set in a prehistoric world forever changed by a cataclysmic event. Step into the role of a young Spinosaurus, wielding a colossal Great Sword. Confront rival dinosaurs, some armed with weapons of their own, all in a desperate fight to prevent a looming extinction.
- 6

Two Worlds Epic Edition
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares RPG with Mutagenic 2.
... 300 years after Aziraal has been banished, a brother and sister are drawn into the conflict which has flared up between the Orcs and the free world. Kyra, the hero's younger sister, suddenly disappears in mysterious circumstances.«...If my family really belongs to the chosen ones, why then have we always been as poor as church mice?
- 7

Grim Dawn
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and Indie with Mutagenic 2.
Enter an apocalyptic fantasy world where humanity is on the brink of extinction, iron is valued above gold and trust is hard earned. This ARPG features complex character development, hundreds of unique items, crafting and quests with choice & consequence.
- 8

Rune Knights
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and Indie with Mutagenic 2.
Rune Knights is a cooperative action RPG focused on customization, crafting, and combat. Customize your character's aesthetics, stats, gameplay, and gear as you battle through procedurally generated and hand-crafted levels with your allies.
- 9

Mutagenic
Single-player alternative to Mutagenic 2 — playable solo, no multiplayer required. Shares Action and Indie with Mutagenic 2.
Mutagenic: A mashup of ARPG and Survivor gameplay, bridging the best of both genres. With unrivaled depth to character customization, Mutagenic has the depth of high-budget ARPG games with the simplified controls of a Survivor-style game. Can you craft a build to outdo everyone else?