Single-player games like Mytosis
Below are 8 single-player Steam games similar to Mytosis, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Mytosis page.
Ranked picks
- 1
Balls & Gamble
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Casual with Mytosis.
Balls & Gamble is a casino-inspired incremental game where you shoot a LOT of balls, earn money, buy upgrades, gamble, unlock new balls, and eventually break reality itself.
- 2
Storm Grill
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mytosis.
A short incremental game where you play as a grill and fight against the storm! Evaporate raindrops, earn coins, unlock new upgrades and skills, grow stronger until you can outlast the downpour.
- 3
Smashing Bottles
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mytosis.
Smashing Bottles is a short and satisfying incremental game where you break bottles to earn money, upgrade your bat, discover new bottles, and cause chaos! Will you smash enough bottles to buy the universe?
- 4
Build a Cat Tower to reach the Fish
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Indie and Casual with Mytosis.
A short incremental game about building a Cat Tower to reach the Fish. Unlock new cats, each with their own color and special ability. Stack them higher and faster for even tastier fish.
- 5
Click Flip
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Simulation with Mytosis.
Click Flip is a short incremental game about clicking tiles, earning points, buying upgrades, and causing crazy tile combos.
- 6
Hydra Heli 2
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mytosis.
Hydra Heli 2 is a relaxing incremental game about sinking battleships with an overpowered helicopter. Command swarms of unstoppable weapons, annihilate armadas, collect shards, and utilize the Depot to boost damage, increase firepower, and unlock new regions.
- 7
Legion Breaker
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mytosis.
A short active incremental game about defending from undead hordes. Wield an arsenal of spells, raise a holy army, and fight across ever-expanding battlefields. Start from nothing and progress through a massive skill tree to become the ultimate battlemage.
- 8
Protect the Pit
Single-player alternative to Mytosis — playable solo, no multiplayer required. Shares Strategy and Simulation with Mytosis.
Attack with your cursor, build towers and walls to defend your pit! An incremental clicker that combines tower defense, maze building, and large upgrade trees. Earn money, upgrade your defenses, and build winding mazes to stop the hordes of the Dark Forest.