Single-player games like Symptoms of Infection
Below are 8 single-player Steam games similar to Symptoms of Infection, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Symptoms of Infection page.
Ranked picks
- 1
Psychiatrist Simulator
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
Have you ever wanted to be a psychiatrist? Now you can! Be a shrink for 14 days. Meet 14 patients with unique story of their lives. Diagnosis, treatment, chosen dialogues have impact on history of patients. The choice is yours.
- 2
Claim Denied!
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
You're an insurance investigator. Review evidence, spot fraud, make decisions. Every case is a puzzle — approve, reject, or negotiate. Limited energy, a ticking clock, and your reputation on the line
- 3
Psychiatrist Simulator 2
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
Take role as Dr. Smith, psychotherapist. Game consists of real people video recordings. Talk with them, treat, learn about psychology. Your choices have consequences, at the end you will see what happened in their life after meeting with you.
- 4
3.2m2
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
Don't try to find achievement in this game. Don't try to make something of your life. You are very nothing. if you only know the room you can use and the duties you have, you can clear this game . . . even your ego
- 5
Until The End
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
In Until The End, you play as Zoe, a young nurse who has just graduated. At the Montagne Institute, you will help her make the best decisions for the well-being of her patients in a palliative care unit.
- 6
CURE - A Hospital Simulator
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation and Early Access with Symptoms of Infection.
Manage the night shift of an ER during the apocalypse, solo or with friends online: Diagnose patients. Design and grow your hospital, and defend against the undead while treating the living. If you're a creator, connect the game to Twitch and make the audience your patients for even more fun!
- 7
Rescue Operations Simulator
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
Rescue Operations Simulator is a game where you play the role of USAR (Urban Search and Rescue) member and a team leader. You will arrange and execute rescue operations from real life catastrophic events that shocked and changed the whole world.
- 8
PAGER
Single-player alternative to Symptoms of Infection — playable solo, no multiplayer required. Shares Simulation with Symptoms of Infection.
You are wetware, working a mysterious job.