Single-player games like Monsters and Medicine
Below are 10 single-player Steam games similar to Monsters and Medicine, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Monsters and Medicine page.
Ranked picks
- 1

LYNE
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Deceptively simple. Infinitely complex. LYNE is a minimalist puzzle game that will knot your brain as it calms your soul. Connect the shapes. Fill the board. Lose yourself in the interflowing paths of LYNE.
- 2

Hexa Turn
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Hexa Turn is a turn-based puzzle game with minimalist design. The logic is simple: block the triange. So, think outside of the box and try not to find a solution. Try to break the solution!
- 3

Dungeon Wizards
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Dungeon Wizards combines classic Rogue-Lite and colorful Match3 with adventurous Roleplay elements. Venture on your very own journey, collect and combine rare relics with powerful spells and face loads of challenging enemies!
- 4

Puzzle Frame
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Enter a quiet place where you can relax and solve sliding puzzles. There's no tracking scores, no hidden doors, and no plot twist, just a zen place for your mind to wander.
- 5

Pirates on Target
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Move the blocks strategically, your objective is to change the trajectory of the cannonballs until they reach the pirate ship. Simple yet challenging.
- 6

Blokker: Orange
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Move the blocks strategically until the balls find the targets. Simple yet challenging! This is Blokker.
- 7

Blokker
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Move the blocks strategically until the balls find the targets. Simple yet challenging! This is Blokker.
- 8

Mini Pipes - A Logic Puzzle Pipes Game
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
A Logic Puzzle Pipes Game with a beautiful minimalist design and a uniquely prepared soundscape. Rotate the pipes until all the pipes are filled with water.
- 9

Terra Nil
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Terra Nil is an intricate environmental strategy game about transforming a barren wasteland into a thriving, balanced ecosystem. Bring life back to a lifeless world by purifying soil, cleaning oceans, planting trees, and reintroducing wildlife, then leave without a trace.
- 10

Jetstream
Single-player alternative to Monsters and Medicine — playable solo, no multiplayer required. Shares Indie and Casual with Monsters and Medicine.
Jetstream is an elegant and relaxing puzzle game where you soar amongst the clouds. Play through dozens of sculpted levels as you guide your plane to its destination. Jetstream has been designed to be a frictionless experience - it’s just you and the puzzles!