Single-player games like Immunity Protocol
Below are 8 single-player Steam games similar to Immunity Protocol, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Immunity Protocol page.
Ranked picks
- 1

Chain of Command
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
Chain of Command is a top-down arena shooter roguelike, where you control a snake-like chain of fighters that attack automatically. Choose your Commander and build your party to create high-synergy builds to crush the invading demon armies.
- 2

Lone Survivors
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
An objective-driven bullet heaven where twelve classes build absurd weapon synergies across shifting fantasy biomes. Raise the dead as a Necromancer, plow through enemies as a Knight, and more! Survive events, bosses, and campaign objectives, then chase endless leaderboard runs.
- 3

Forecast Death
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
Survive the chaos of a bullet-heaven action game. Tear through enemy hordes, stack wild ability combos, and endure cataclysms that rewrite the rules mid-fight. The pace ramps up every minute - either you grow stronger, or you get wiped out.
- 4

Fading Reel
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
A sepia Roguelike — lead a chained squad through 22 waves. Map events split your line, milestone recruits add firepower. Linked Blink, run upgrades, 19 Evolutions, and a permanent meta tree carry you to the final Boss Hydra.
- 5

ALL EYES ON ME
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
Everyone sees the same thing. Except you. Now every eye is on you. Thousands of eyes hunt you in this bullet heaven roguelite. Their attention makes them deadlier and charges your strongest weapon. Find items, shape your build, beat challenges, play local co-op or online conquests.
- 6

Micron Survivor
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action with Immunity Protocol.
Micron Survivor is a survival game with rogue-lite elements where you play as alien microorganisms under the microscope. Evolve, unlock research objectives, find symbiotic weapons, upgrade your builds, and fight hordes of terrestrial organisms to rule the microcosm.
- 7

Let Them Come: Onslaught
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action with Immunity Protocol.
Survive the relentless offensive of the alien horde in Let Them Come: Onslaught, a sci-fi survival roguelite. The pursuit of the perfect build and an ever-expanding arsenal of abilities are the keys to your success.
- 8

Noobs Are Coming
Single-player alternative to Immunity Protocol — playable solo, no multiplayer required. Shares Action and Indie with Immunity Protocol.
YOU ARE THE FINAL BOSS. Brutal synergy arena roguelike. Pick your Final Boss character, equip boss patterns and combine tons of attacks to create unique builds. Play solo or in co-op!