Single-player games like Mycelium Conquest: Mitosis
Below are 9 single-player Steam games similar to Mycelium Conquest: Mitosis, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Mycelium Conquest: Mitosis page.
Ranked picks
- 1
Mycelium Conquest
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
A deep biological network automation game where you grow a living mycelial network across an alien planet. Consume the local flora and creatures, build biological production chains, and evolve from a tiny spore into a cosmic entity that consumes worlds.
- 2
Belts of Iron
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
Explore, automate, and fight in this new open world factory automation game. Build factories connected by miles of conveyor belts. Manage power and fluid networks. Explore procedurally generated worlds filled with resources to harvest and hostile creatures to defeat. Play solo or online with friends
- 3
Settletopia
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Simulation with Mycelium Conquest: Mitosis.
Grow a small colony into a vast, world-spanning civilization. Play solo or with friends as you gather resources, build cities, manage colonist needs, explore uncharted lands, establish logistics, raise armies, forge alliances, and wage wars—all in a living world.
- 4
Planet Gemini
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
Planet Gemini is a factory-building and tower defense game. After crash-landing on two planets during an interdimensional journey, fend off waves of enemies and research a portal to survive.
- 5
Substructure
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Simulation with Mycelium Conquest: Mitosis.
Harness the power of automation in this factory game set on a rogue planet in the far reaches of the solar system. Dig down and explore the depths of an alien world, exploit its resources across complex production chains, and travel towards the core to uncover its deepest secrets.
- 6
Per Aspera
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
Make Mars your own! Take control of the world’s most sophisticated AI (AMI) and terraform the surface of the Red Planet for a city-building experience on a planetary scale. Transform this barren world into a lush paradise and explore the surface for any ancient secrets that may be waiting.
- 7
Train Valley World
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
Train Valley World is an engrossing transport tycoon inspired by the genre classics. Build and manage efficient railroads across the globe, create sophisticated logistics chains, design your own levels, and become a business mogul – solo or in multiplayer!
- 8
Techtonica
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy and Indie with Mycelium Conquest: Mitosis.
Techtonica is a first-person factory automation game with a gripping mystery about mining your way out from the depths of an alien planet. Explore bioluminescent caves, mold destructible terrain, construct a massive subterranean factory. Dig your way toward answers & discover the secrets of Calyx.
- 9
Keep The Ammo Flowing
Single-player alternative to Mycelium Conquest: Mitosis — playable solo, no multiplayer required. Shares Strategy with Mycelium Conquest: Mitosis.
A top-down incremental logistics and tower-defense game. Mine resources, produce ammunition, build tracks toward the exit, and upgrade your mobile furnace and turret while defending it from underground swarms.