Single-player games like The Book of Plagues 2
Below are 9 single-player Steam games similar to The Book of Plagues 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like The Book of Plagues 2 page.
Ranked picks
- 1
The Book of Plagues
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
The city is drowning in Plague. Panic, hunger, and fear are tearing it apart. You are the last one who can change its fate: heal it, hold it back from collapse… or drive it to ruin with your own hands!
- 2
GlobalQuarantine
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Running an international organization called the Global Quarantine Bureau, dealing with pandemics and public health issues worldwide, while also ensuring increasing revenue and personal enrichment.
- 3
Save Us, Doctor Faust!
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Save Us, Doctor Faust! is an immersive medieval doctor simulator where you diagnose diseases, study medicine, and craft remedies from raw ingredients. Examine your patients, grind and distill ingredients, experiment with recipes — and remember: one mistake could cost a life.
- 4
Galacticare
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams.
- 5
Organomancer
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Run an organ trading empire in the dark underworld of Arkwright. Buy, upgrade, and sell organs across black markets. Manage your economy, dodge the police, and fulfill patient requests to dominate the underground.
- 6
Execute
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Kill everyone in the world with a guillotine… on a cursed Win98 desktop.
- 7
The Kindeman Remedy
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
The most blasphemous, diabolical and insane management game ever created. Aided by a lascivious nun in a grim prison, rig executions, conduct horrid experiments and do the unspeakable to cook up your cure-all: The Kindeman Remedy. Do not be afraid. This time, you're the monster.
- 8
Psychiatrist Simulator
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required. Shares Simulation with The Book of Plagues 2.
Have you ever wanted to be a psychiatrist? Now you can! Be a shrink for 14 days. Meet 14 patients with unique story of their lives. Diagnosis, treatment, chosen dialogues have impact on history of patients. The choice is yours.
- 9
Captain Goose
Single-player alternative to The Book of Plagues 2 — playable solo, no multiplayer required.
Embark on a dangerous journey with the crew of the brave Captain Goose! The sailors will have to reach the very edge of the World to break a terrible curse. However, the Abyss will do everything possible to prevent this...