Single-player games like Diseased
Below are 8 single-player Steam games similar to Diseased, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Diseased page.
Ranked picks
- 1

MAPS (My Apocalyptic Plan for Survival)
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Strategy and Indie with Diseased.
Coming Soon
- 2

Phantom of the Grove
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Action and Strategy with Diseased.
A fungal fairycore colony sim where you are the vengeful spirit of an ancient forest. Possess and gaslight invaders into fighting each other, reclaim their bodies as fuel for the Grove, and guide your Seely mushroom children to build and expand. The Grove is done being nice.
- 3

Project Tomorrow
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Strategy with Diseased.
A base-building survival game with terraforming and crafting. Earth lies poisoned and abandoned ten thousand years after invasion. Awaken from stasis, defend your fragile foothold, and restore a dead world so humanity can live here again.
- 4

Ascent of Ashes
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Strategy and Indie with Diseased.
A colony sim set in a post-apocalyptic dystopia. Build and defend your base. Manage your survivors. Engage raiders, aliens, Remnant soldiers and other factions in real-time-with-pause combat. Or use stealth to outwit them. Explore the massive world. Survive at all costs
- 5

Steel Artery: Train City Builder
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Strategy and Indie with Diseased.
Build a living city on rails in this steampunk fantasy train-city builder. Manage multiracial colonies with thousands of autonomous citizens, balance their needs, manage the economy, and create logistics as you explore distant regions to ensure the prosperity of your Empire.
- 6

Until We Die
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Action and Strategy with Diseased.
Until We Die is a side-scrolling strategy game about defending your base where you have to run around as Ivan, assign tasks to people, and fight mutants in the post-apocalyptic subway!
- 7

Eastern Era
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Strategy and Indie with Diseased.
To escape from pursuit, as the leader of your sect, guide your disciples to rise again! Engage in farming and hunting, train in martial arts, and forge weapons and armor. Build your sect's base and fortifications from the ground up to survive in this perilous, ambition-filled martial world!
- 8

Monsters are Coming!
Single-player alternative to Diseased — playable solo, no multiplayer required. Shares Action and Strategy with Diseased.
Beware, Monsters are Coming! In this Tower-Survivor rogue-lite, you protect an ever-moving city from unrelenting hordes. Gather resources, fortify defences, and survive for as long as you can. Will you reach the Ark?