Single-player games like Pestis
Below are 9 single-player Steam games similar to Pestis, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Pestis page.
Ranked picks
- 1
Propa.
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Simulation with Pestis.
In this RTS game, control your virus to replicate and evolve against a powerful immune system. Equip gene segments to create unique viral armies. Use tactics to eliminate immune cells or achieve escape. Develop strategies for domination and enjoy endless strategic fun!
- 2
Backrooms: Partygoers
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
Backrooms: Partygoers is a backrooms horror game based on Level 0 where you play as a researcher tasked to find anomalies inside the backrooms. You are equip with devices that can beep whenever an anomaly is near, where the partygoers roam and can hear you.
- 3
Ministry of Pandemic
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
Ministry of Pandemic is a strategy and simulation game that forces social and economic balance during the pandemic. Formulate your strategy for survival while keeping all aspects of society steady.
- 4
Covid Simulator
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
COVID SIMULATOR is an outbreak simulation that visualizes how quickly Covid-19 spreads, becoming a disaster. The game is an open sandbox where you can add (or remove) Covid mandates and see what happens! Create your workplace, enact your mandates, and roll the dice with your workers.
- 5
Herbalist Roman
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Simulation with Pestis.
Step into the role of a medieval herbalist. Study your herbal book, craft macerations, and help your clients by easing their ailments. Christianity is reaching the Slavic village of Drebor, and your choices will determine whether these changes unfold in peace.
- 6
Physician Simulator
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
A district physician simulator. See patients, review lab results, make diagnoses and write prescriptions. Real doctors say they recognize themselves. Every decision has consequences.
- 7
Virtual Chemistry Lab
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
This is a serious game. Made for educational purposes. It was made in order to enable students to understand the high school chemistry curriculum and to provide equality of opportunity.
- 8
AnyCircuit
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
Build the digital machines you've always dreamed of! With some patience, love for digital electronics, and a good amount of problem-solving skills, you can create any combinational or sequential circuit in no time, thanks to the user-friendly interface and integrated voxel-editing tools.
- 9
Temptation
Single-player alternative to Pestis — playable solo, no multiplayer required. Shares Indie and Simulation with Pestis.
Temptation - a game about a medieval priest who is suddenly possessed by a demon. Your goal is to perform an unusual ritual of exorcism to banish the demon from himself!