Single-player games like Auto Immune
Below are 8 single-player Steam games similar to Auto Immune, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Auto Immune page.
Ranked picks
- 1

Kings & Savages
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy and Early Access with Auto Immune.
A fast-paced, high skill Solo/Auto-Battler. Easy to learn, hard to master. Inspired by Chess and Dota.
- 2

Decoherence
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy with Auto Immune.
Build robots, devise a battle plan and fight alongside them!
- 3

Insectum - Epic Battles of Bugs
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy with Auto Immune.
Immerse yourself in the epic battles of "Insectum" and unleash the power of your monstrous insects. Face off against your rivals on the battlefield by strategically using cards.
- 4

SolForge Fusion
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy and Casual with Auto Immune.
SolForge Fusion is a collectible card-battler where you are a mighty Forgeborn. Command fierce creatures, cast powerful spells, level up your cards, and crush your foes to earn glorious rewards. Created by Richard Garfield (Magic: The Gathering) and Justin Gary (Ascension).
- 5

Wireworks
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy with Auto Immune.
Design your defenses, build your module board, and manage your wires. Combine signals and create synergies to empower your weapons and survive in this base-defense roguelike auto-battler.
- 6

Loopstructor
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy and Casual with Auto Immune.
This is a strategy game that combines tower defense with Roguelike. Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defense loop and build battle trains to defend against enemy attacks.
- 7

Godslayer Arena
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy and Early Access with Auto Immune.
Godslayer Arena is a roguelike fusion of autobattlers and action-rpgs. Combat is performed completely automatically. Understanding complex interactions between the spells, gems, and items you draft will be key to success. Break the game. Become overpowered.
- 8

Turnbound
Single-player alternative to Auto Immune — playable solo, no multiplayer required. Shares Strategy and Early Access with Auto Immune.
Turnbound is an auto battler, where you manage a hero's inventory to escape a haunted boardgame. Each run is different from the last, with unique upgrades, combos and synergies. Async PvP lets you battle the ghosts of other players at your own pace in this unique new inventory battler.