Games like Ex Vitro
EX VITRO is a dark sci-fi 2D platformer where you delve into the ruins of a military research facility and discover the horrors within. Whether machine, creature, or something else entirely, you’ll face the violent legacy of the last survivors of humanity.

Top 12 games similar to Ex Vitro
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Quarion
A short 2D pixel-style metroidvania where you explore, fight bosses, aquire items and abilities and find secrets. Inspired by games such as You Have to Win the Game and VVVVVV.
AdventureIndie - 2

DOOMBLADE
Deep underground, Gloom Girl discovers DOOMBLADE, a sentient weapon hellbent on escape after eons in chains. Together, “Doom and Gloom” embark on a vengeful quest to unlock the powerful abilities and destroy the Dread Lords once and for all in this 2D Action Metroidvania.
ActionAdventureIndie - 3

BIOMORPH
BIOMORPH is a dark metroidvania game where you become the creatures that you kill! Solve ingenious puzzles and navigate a stunning hand-drawn world. Meet quirky characters, rebuild a city, and uncover the secrets of a sprawling, fallen civilization… and of your own mysterious origins.
ActionAdventure - 4

ANIMAL WELL
Explore a dense, interconnected labyrinth, and unravel its many secrets. Collect items to manipulate your environment in surprising and meaningful ways. Encounter beautiful and unsettling creatures, as you attempt to survive what lurks in the dark. There is more than what you see.
ActionAdventureIndie - 5

Mable & The Wood
Hunt down massive beasts and, upon destroying them, shapeshift into their forms in order to use their powers to save or destroy the world. Players with less violent intent can find secret paths to complete Mable without killing anything, including bosses.
ActionAdventureIndie - 6

Waking Mars
In 2097, life is discovered on Mars. When your mission of first contact becomes trapped by a cave-in, you must master the alien ecosystem to survive. Soon you stumble upon more than anyone expected, and with time running out, you will make a decision that determines the fate of a lost planet.
ActionAdventureIndie - 7

Constance
Constance is a 2D hand-drawn action adventure featuring a paintbrush-wielding artist, striving to escape from a colorful but decaying inner-world, created by her declining mental health.
ActionAdventureIndie - 8

Timespinner
Travel back in time to change fate itself, in this beautifully crafted story-driven adventure, inspired by classic 90s action-platformers. Join timekeeper Lunais on her quest for revenge against the empire that killed her family, using time-bending powers to explore a vast, connected world.
ActionAdventureIndie - 9

Recompile
This atmospheric, Metroidvania hacking adventure lets you take control of a semi-sapient program struggling against deletion. In the sprawling 3D world of a Mainframe, Recompile features intense combat, tight 3D platforming, super-powered abilities and an environmental logic-based hacking mechanic.
ActionAdventureIndie - 10

Hollow Knight
Forge your own path in Hollow Knight! An epic action adventure through a vast ruined kingdom of insects and heroes. Explore twisting caverns, battle tainted creatures and befriend bizarre bugs, all in a classic, hand-drawn 2D style.
ActionAdventureIndie - 11

Zapling Bygone
Zapling Bygone is a twisted metroidvania where you murder your foes and steal their abilities by wearing their skulls and absorbing their consciousness into your hive-mind.
ActionAdventureIndie - 12

Reventure
The one and only non-linear adventure with 100 different endings. Don't just wishlist me. I'm not that expensive... also, look at those reviews!
AdventureIndie
About imho.run
imho.run is a Steam game recommender that combines collaborative filtering (ALS / iALS / EASE / LightGCN) with content-based scoring over genres, categories, Steam tags, developers, and publishers, plus AI-extracted gameplay vibes from review text. The lists you see here are generated in seed mode — anchored on Ex Vitro— so they answer the question “what plays like this?” rather than “what fits my library?”
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