Single-player games like Ex Vitro
Below are 11 single-player Steam games similar to Ex Vitro, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Ex Vitro page.
Ranked picks
- 1
BIOMORPH
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Adventure with Ex Vitro.
BIOMORPH is a dark metroidvania game where you become the creatures that you kill! Solve ingenious puzzles and navigate a stunning hand-drawn world. Meet quirky characters, rebuild a city, and uncover the secrets of a sprawling, fallen civilization… and of your own mysterious origins.
- 2
DOOMBLADE
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
Deep underground, Gloom Girl discovers DOOMBLADE, a sentient weapon hellbent on escape after eons in chains. Together, “Doom and Gloom” embark on a vengeful quest to unlock the powerful abilities and destroy the Dread Lords once and for all in this 2D Action Metroidvania.
- 3
Quarion
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Indie and Adventure with Ex Vitro.
A short 2D pixel-style metroidvania where you explore, fight bosses, aquire items and abilities and find secrets. Inspired by games such as You Have to Win the Game and VVVVVV.
- 4
Mable & The Wood
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
Hunt down massive beasts and, upon destroying them, shapeshift into their forms in order to use their powers to save or destroy the world. Players with less violent intent can find secret paths to complete Mable without killing anything, including bosses.
- 5
Derelict Star
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Adventure with Ex Vitro.
A precise momentum-based platformer that emphasizes exploration and navigation puzzles. Run and jump your way through a wide variety of obstacles and challenges as you explore an abandoned derelict freighter. Be careful: getting in is often easier than getting out!
- 6
ANIMAL WELL
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
Explore a dense, interconnected labyrinth, and unravel its many secrets. Collect items to manipulate your environment in surprising and meaningful ways. Encounter beautiful and unsettling creatures, as you attempt to survive what lurks in the dark. There is more than what you see.
- 7
Waking Mars
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
In 2097, life is discovered on Mars. When your mission of first contact becomes trapped by a cave-in, you must master the alien ecosystem to survive. Soon you stumble upon more than anyone expected, and with time running out, you will make a decision that determines the fate of a lost planet.
- 8
Recompile
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
This atmospheric, Metroidvania hacking adventure lets you take control of a semi-sapient program struggling against deletion. In the sprawling 3D world of a Mainframe, Recompile features intense combat, tight 3D platforming, super-powered abilities and an environmental logic-based hacking mechanic.
- 9
Mycocosm
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action with Ex Vitro.
MYCOCOSM is a casual arcade shooter and resource manager where you take the role of a newly sprouted seedling. Fight off waves of soil-borne enemies using antimicrobial chemicals, and trade for precious nutrients with wandering fungal spores - but beware their deceitful dealings.
- 10
Hollow Knight
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
Forge your own path in Hollow Knight! An epic action adventure through a vast ruined kingdom of insects and heroes. Explore twisting caverns, battle tainted creatures and befriend bizarre bugs, all in a classic, hand-drawn 2D style.
- 11
A Robot Named Fight!
Single-player alternative to Ex Vitro — playable solo, no multiplayer required. Shares Action and Indie with Ex Vitro.
A Robot Named Fight is a Metroidvania roguelike focused on exploration and item collection. Explore a different, procedurally-generated labyrinth each time you play and discover randomized power-ups to traverse obstacles, find secrets and explode meat beasts.