Single-player games like Super Infection Massive Pathology
Below are 8 single-player Steam games similar to Super Infection Massive Pathology, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Super Infection Massive Pathology page.
Ranked picks
- 1
Steel Swarm: SURVIVOR
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
Steel Swarm: SURVIVOR is a fast-paced roguelite survivors game where you obliterate swarms with your drones. Set up formations, upgrade your drones, and overwhelm hordes of metal in each run. Take on enemy waves solo or in multiplayer co-op!
- 2
Mighty X Arms
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
Mighty X Arms is a roguelike survivor inspired by Brotato, featuring collectible weapon-creatures called Arms. Build your loadout, upgrade them, and mow down enemy swarms to survive.
- 3
Compadrone: Land Wars
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.
- 4
Noobs Are Coming
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
YOU ARE THE FINAL BOSS. Brutal synergy arena roguelike. Pick your Final Boss character, equip boss patterns and combine tons of attacks to create unique builds. Play solo or in co-op!
- 5
Void Resurgence
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
Command a starship in Void Resurgence, a retro-futuristic space roguelite. Battle through colorful cosmic fields, collect upgrades, and build your ultimate ship. Dodge intense bullet-hell patterns and fight for survival. Every run offers new challenges and permanent progress.
- 6
Forecast Death
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
Survive the chaos of a bullet-heaven action game. Tear through enemy hordes, stack wild ability combos, and endure cataclysms that rewrite the rules mid-fight. The pace ramps up every minute - either you grow stronger, or you get wiped out.
- 7
Arms of God
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
Gear up for a battle through hell in this roguelite Bullet Heaven Arena Autoshooter with Doom-inspired gore vibes, metal music, and a satisfying combat feel. Wield five weapons at once, upgrade and merge them to forge indestructible builds, and bring divine justice to a world on the brink of chaos.
- 8
Genome Guardian 2
Single-player alternative to Super Infection Massive Pathology — playable solo, no multiplayer required. Shares Action and Indie with Super Infection Massive Pathology.
COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!