Games like Genome Guardian 2
COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
Players who liked Genome Guardian 2 also play
Ranked by collaborative filtering across millions of Steam libraries plus content overlap on genres, tags, and developers.
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Compadrone: Land Wars
In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.
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Supre-Immune
Join a roguelike action where cute immune cells battle viruses. Collect data in fast-paced combat, gain weapons and abilities through evolution, or level up to grow stronger. The fun of building your own super immune cell with different combinations each run is up to you!
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Vital Shell
Vital Shell is a single player top-down arena shooter that puts you in control of mechs inspired by classic fantasy archetypes. Unlock powerful synergies with unique weapons, traits, and abilities as you take on increasingly challenging waves of enemies in a shattered realm.
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Genome Guardian
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
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Galactic Vault
Build your weapon to its full potential in Galactic Vault, a fast-paced FPS roguelite. Discover endless upgrade combinations, craft diverse builds, and unleash devastating abilities. Get ready to infiltrate high-security vaults and recover lost tech.
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Sexy Mystic Survivors
Roguelite bullet-hell combat meets sexy anime action in Sexy Mystic Survivors, as you rise to the occasion to help gorgeous heroines destroy countless invading monsters. Plan your builds, upgrade heroines, and survive against the clock. Keep the heroines alive and they’ll be sure to reward you!
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Gunlocked 2
Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!
Reviewers mention these as similar to Genome Guardian 2
Surfaced from review text: when other players write 'if you liked X, try Y', we catch the name and resolve it back to a Steam game.
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Genome Guardian
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
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Cell Command
TURN-BASED TACTICS meets SNAKE: A new roguelike in the Genome Guardian universe. SPLICE DNA to create new units, enhance their genetics, and take on the Abyss virus once more in a variety of different modes & match types.
Cheaper alternatives
Games in the same vein priced at least 40% below Genome Guardian 2 at current Steam store prices.
- 1
Compadrone: Land Wars
In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.
- 2
Supre-Immune
Join a roguelike action where cute immune cells battle viruses. Collect data in fast-paced combat, gain weapons and abilities through evolution, or level up to grow stronger. The fun of building your own super immune cell with different combinations each run is up to you!
- 3
Vital Shell
Vital Shell is a single player top-down arena shooter that puts you in control of mechs inspired by classic fantasy archetypes. Unlock powerful synergies with unique weapons, traits, and abilities as you take on increasingly challenging waves of enemies in a shattered realm.
Plays great on Steam Deck
Valve-Verified or Playable picks from the similar pool — ready to go on Deck out of the box.
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Vital Shell
Vital Shell is a single player top-down arena shooter that puts you in control of mechs inspired by classic fantasy archetypes. Unlock powerful synergies with unique weapons, traits, and abilities as you take on increasingly challenging waves of enemies in a shattered realm.
- 3
Gunlocked 2
Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!
Frequently asked about Genome Guardian 2
- Does Genome Guardian 2 run on Steam Deck?
- Genome Guardian 2 is rated Playable on Steam Deck — it runs, but expect some manual adjustments (control remapping, text size, or graphics settings) for the best experience.
- How much does Genome Guardian 2 cost?
- Genome Guardian 2 is listed on Steam at 15.99 USD (current store price; Steam sales may reduce this temporarily).
- What games are most similar to Genome Guardian 2?
- Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Genome Guardian 2 are Compadrone: Land Wars, Supre-Immune, Sektori.
- Who developed Genome Guardian 2?
- Genome Guardian 2 was developed by Alpherior.
imho.run ranks Steam game alternatives using a mix of collaborative filtering (ALS / iALS / EASE / LightGCN), content scoring over genres, categories, Steam tags, developers, and publishers, plus AI-extracted vibes mined from review text. The page above is generated in seed mode anchored on Genome Guardian 2.
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