Games like Genome Guardian 2
If Genome Guardian 2 is your kind of game, the closest matches are Compadrone: Land Wars, Supre-Immune and Deep Breach — picked from the ranked list below. Reviewers single out its atmospheric, challenging and dark. Each pick is ranked by what players of this game also play, shared genres and tags, and review-mined similarity — not a generic popularity list.
Get personalized picks →About Genome Guardian 2: COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
Players who liked Genome Guardian 2 also play
Steam players who put hours into Genome Guardian 2 also tend to own these titles — a signal called collaborative filtering. imho.run cross-references millions of library ownership patterns to surface games whose real audiences overlap, regardless of whether their genre tags match.
Compadrone: Land Wars
WHY THIS
Shares loadout customization, wave based combat, arcade style and an intense mood with Genome Guardian 2.
Top pick for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
In this fast-paced roguelite arena shooter with tower-defense twists, control a drone capable of wielding multiple weapons and fight hordes of alien warbots. Collect resources and XP to unlock new weapons, towers, abilities, and drones.
Supre-Immune
WHY THIS
Second-strongest match for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
Join a roguelike action where cute immune cells battle viruses. Collect data in fast-paced combat, gain weapons and abilities through evolution, or level up to grow stronger. The fun of building your own super immune cell with different combinations each run is up to you!
Deep Breach
WHY THIS
Third-strongest match for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
Deploy orbital defenses, fuse experimental turret technologies, and engineer devastating weapon builds in a tactical sci-fi horde survival roguelike. Break shields, shred armor, and adapt to evolving bio-corrupted swarms alongside a damaged tactical AI.
Genome Guardian
WHY THIS
Shares wave based survival, loadout customization, roguelite and an atmospheric mood with Genome Guardian 2.
Ranked #4 for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Lost Galaxy: Survivors
WHY THIS
Ranked #5 for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Casual with Genome Guardian 2.
Defend massive interdimensional portals against relentless alien swarms in this fast-paced sci-fi top-down survival shooter.
MassEve
WHY THIS
Ranked #6 for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
You are a massive neutrino. Craft quantum builds, clash with other subatomic particles, and survive a universe that reshapes every run. A fast-paced twin-stick roguelike where real physics bends the rules.
Tankron
WHY THIS
Ranked #7 for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.
Cosmic Flesh: Overdrive
WHY THIS
Ranked #8 for Genome Guardian 2 fans by collaborative filtering across millions of Steam libraries. Shares Action and Indie with Genome Guardian 2.
Defend the galaxy from endless cosmic horrors. Dash and blast with fast, burst-based piloting, unleash powerful overdrives, evolve your ship with each unique run, and push your skills to the limit.
Reviewers mention these as similar to Genome Guardian 2
Surfaced from review text: when other players write 'if you liked X, try Y', we catch the name and resolve it back to a Steam game.
Nova Drift
WHY THIS
Shares a hypnotic mood with Genome Guardian 2.
Reviewers of Genome Guardian 2 cross-mention this title as a similar play. Shares Action and Indie with Genome Guardian 2.
Nova Drift distills the mechanical depth and strategy of an ARPG into classic arcade space combat. Control an endlessly evolving bio-mechanical ship, face legions of strange and deadly foes, and ride the wake of a dying star across the void.
ROUNDS
WHY THIS
Shares a funny mood with Genome Guardian 2.
Reviewers of Genome Guardian 2 cross-mention this title as a similar play. Shares Action and Indie with Genome Guardian 2.
Rounds is a 1v1 rogue-lite shooter where each round gets more intense. The losing player of each round unlocks clever upgrades to create a better build to counter their opponent.
Balatro
WHY THIS
Shares build crafting, roguelike progression and a hypnotic mood with Genome Guardian 2.
Reviewers of Genome Guardian 2 cross-mention this title as a similar play. Shares Indie and Casual with Genome Guardian 2.
The poker roguelike. Balatro is a hypnotically satisfying deckbuilder where you play illegal poker hands, discover game-changing jokers, and trigger adrenaline-pumping, outrageous combos.
Genome Guardian
WHY THIS
Shares wave based survival, loadout customization, roguelite and an atmospheric mood with Genome Guardian 2.
Reviewers of Genome Guardian 2 cross-mention this title as a similar play. Shares Action and Indie with Genome Guardian 2.
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!
Cell Command
WHY THIS
Shares loadout customization, build variety, roguelite and an atmospheric mood with Genome Guardian 2.
Reviewers of Genome Guardian 2 cross-mention this title as a similar play. Shares Indie and RPG with Genome Guardian 2.
TURN-BASED TACTICS meets SNAKE: A new roguelike in the Genome Guardian universe. SPLICE DNA to create new units, enhance their genetics, and take on the Abyss virus once more in a variety of different modes & match types.
Cheaper alternatives
Games in the same vein priced at least 40% below Genome Guardian 2 at current Steam store prices.
Garry's Mod
WHY THIS
Priced ~69% under Genome Guardian 2 on Steam right now. Shares Indie and Casual with Genome Guardian 2.
Garry's Mod is a physics sandbox. There aren't any predefined aims or goals. We give you the tools and leave you to play.
Vampire Survivors
WHY THIS
Priced ~69% under Genome Guardian 2 on Steam right now. Shares Action and Indie with Genome Guardian 2.
Mow down thousands of night creatures and survive until dawn! Vampire Survivors is a gothic horror casual game with rogue-lite elements, where your choices can allow you to quickly snowball against the hundreds of monsters that get thrown at you. Be the bullet hell!
R.E.P.O.
WHY THIS
Priced ~56% under Genome Guardian 2 on Steam right now. Shares Action and Early Access with Genome Guardian 2.
An online co-op horror game with up to 6 players. Locate valuable, fully physics-based objects and handle them with care as you retrieve and extract to satisfy your creator's desires.
PEAK
WHY THIS
Priced ~50% under Genome Guardian 2 on Steam right now. Shares Action and Indie with Genome Guardian 2.
PEAK is a co-op climbing game where the slightest mistake can spell your doom. Either solo or as a group of lost nature scouts, your only hope of rescue from a mysterious island is to scale the mountain at its center. Do you have what it takes to reach the PEAK?
Titanfall® 2
WHY THIS
Priced ~72% under Genome Guardian 2 on Steam right now. Shares Action with Genome Guardian 2.
Respawn Entertainment gives you the most advanced titan technology in its new, single player campaign & multiplayer experience. Combine & conquer with new titans & pilots, deadlier weapons, & customization and progression systems that help you and your titan flow as one unstoppable killing force.
Slay the Spire
WHY THIS
Priced ~61% under Genome Guardian 2 on Steam right now. Shares Indie with Genome Guardian 2.
We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!
Inscryption
WHY THIS
Priced ~50% under Genome Guardian 2 on Steam right now. Shares Indie with Genome Guardian 2.
Inscryption is an inky black card-based odyssey that blends the deckbuilding roguelike, escape-room style puzzles, and psychological horror into a blood-laced smoothie. Darker still are the secrets inscrybed upon the cards...
Cookie Clicker
WHY THIS
Priced ~69% under Genome Guardian 2 on Steam right now. Shares Indie and Casual with Genome Guardian 2.
An idle game about making cookies! Originally released in 2013 on the web, and actively developed since then. This is the official version for Steam.
Free alternatives
Free-to-play games that recommended players of this title also tend to enjoy.
STRAFTAT
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action with Genome Guardian 2.
STRAFTAT is a 1v1/2v2 ONLINE first person SHOOTER with quick rounds in over 350 MAPS ; Including all WEAPONS, proximity chat and 4 players FFA.
Eternal Senia
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Genome Guardian 2.
Thoughts and expectations ARPG
Disfigure
WHY THIS
Shares an intense mood with Genome Guardian 2.
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Genome Guardian 2.
Disfigure is a grim-dark action rogue-like where you battle relentless hordes of monsters lurking in the shadows. Unlock powerful weapons, craft god-like builds with hundreds of upgrades, slay colossal bosses, and push your limits in intense 20–30 minute survival runs!
Princess Remedy in a World of Hurt
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Genome Guardian 2.
Remedy, a recent graduate from the Saturnian healing school, must descend to Hurtland and use her powers to heal everyone from stray ducks to dark lords, and finally cure the ailing Prince Hingst. It's a short, whimsical adventure with plenty of heart(s).
Die in the Dungeon: Origins
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie and RPG with Genome Guardian 2.
Fight your way through a mysterious dungeon in this deck-building, turn-based roguelike game where you don't use cards, but DICE! Deal with enemies by combining dice on your board, boost their effects with magical relics, and discover the story behind Die in the Dungeon!
I MAED A GAM3 W1TH Z0MB1ES 1N IT!!!1
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Action and Indie with Genome Guardian 2.
A top down twin stick zombie slaying shooter that you are sure to play again and again!
Epic Battle Fantasy 3
WHY THIS
Free-to-play pick from the same recommendation pool — no purchase to try it. Shares Indie and RPG with Genome Guardian 2.
Epic Battle Fantasy 3 is a silly turn-based JRPG, full of useless NPCs, rabid cats, childish humor, unreasonably large weapons, anime boobs, and other nonsense. And it's totally free!
Narrow it down
Head-to-head comparisons
Frequently asked about Genome Guardian 2
- Does Genome Guardian 2 run on Steam Deck?
- Genome Guardian 2 is rated Playable on Steam Deck — it runs, but expect some manual adjustments (control remapping, text size, or graphics settings) for the best experience.
- How much does Genome Guardian 2 cost?
- Genome Guardian 2 is listed on Steam at 15.99 USD (current store price; Steam sales may reduce this temporarily).
- What games are most similar to Genome Guardian 2?
- Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Genome Guardian 2 are Compadrone: Land Wars, Supre-Immune, Deep Breach.
- Who developed Genome Guardian 2?
- Genome Guardian 2 was developed by Alpherior.
imho.run ranks Steam game alternatives using a mix of collaborative filtering (ALS / iALS / EASE / LightGCN), content scoring over genres, categories, Steam tags, developers, and publishers, plus AI-extracted vibes mined from review text. The page above is generated in seed mode anchored on Genome Guardian 2.
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