Single-player games like PROJECT M.E.D.S.
Below are 8 single-player Steam games similar to PROJECT M.E.D.S., ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like PROJECT M.E.D.S. page.
Ranked picks
- 1
NeuroSquad - Slay the Horde
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
Invent your own weapons in this sci-fi Roguelike shooter! Combine any weapon with any upgrade to customize your arsenal. Form a squad of holographic soldiers, redesign their guns too, and slay hordes of cybernetic enemies!
- 2
E-Lich: Corporate Souls
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
There’s no R.I.P at E-Lich Corp! Explore the afterlife in this roguelite bullet heaven that is all about humor, insane power-levels, replayability and awful office jokes. Reap souls along your undead coworkers in a company that values your life. And death. Literally.
- 3
One More Run
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
Dive into a world that blends frenetic roguelite action with deep systems and content-rich exploration. Explore densely populated maps to unlock the secrets of a fantasy world under siege by a mechanical threat.
- 4
ERLIK
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
A Turkic folk-horror bullet-heaven roguelite. Every run drifts between two gods; feed Erlik's corruption for savage power and lifesteal, or rise toward Tengri's light for shields and renewal. Every weapon evolves down two opposed paths. Survive the Long Night.
- 5
Hell Maiden
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
Traverse the depths of Hell and beat its toughest demons on your way to Heaven in this horde survival deck-building game inspired by Dante's Divine Comedy.
- 6
Arms of God
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
Gear up for a battle through hell in this roguelite Bullet Heaven Arena Autoshooter with Doom-inspired gore vibes, metal music, and a satisfying combat feel. Wield five weapons at once, upgrade and merge them to forge indestructible builds, and bring divine justice to a world on the brink of chaos.
- 7
Nishin Difenda
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
A chaotic 2D action roguelite where an egg cell guardian fights waves of Enemies, upgrades biological defenses, builds antibody turrets, and survives a ridiculous educational bullet heaven.
- 8
Order of Beast
Single-player alternative to PROJECT M.E.D.S. — playable solo, no multiplayer required. Shares Action and Indie with PROJECT M.E.D.S..
A dark fantasy top-down action roguelite survivor game. Choose an outcast hero, forge evolving skills, collect strange relics, and survive wave after wave until you face the old lords who still rule the ruins.