Single-player games like Total Biochem
Below are 9 single-player Steam games similar to Total Biochem, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Total Biochem page.
Ranked picks
- 1
Trailmarks
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Indie with Total Biochem.
Trailmarks is a turn-based trivia strategy game where you circumnavigate the planet as a broke fact-checker. Chart your own adventurous route across 1,200 real-world cities, answer 120,000+ curated questions, trade souvenirs, and prove your expertise to unlock new countries.
- 2
Sudoku Kingdom
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Indie with Total Biochem.
Beyond the classic 9×9: 22 Sudoku modes and tens of thousands of puzzles, including Killer, Thermometer, Arrow, Jigsaw, Circular, Triangle, Snowflake and Cube boards. Multiple difficulties, notes, undo and hints. One purchase—no ads, energy or microtransactions.
- 3
Bible Quiz: Trivia Game
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Indie with Total Biochem.
Race the clock across hundreds of Bible trivia questions! Test your knowledge of scripture, famous figures, miracles, parables, and more. Perfect for faith communities, trivia fans, and anyone curious about the world's most read book.
- 4
Lifeguard Simulator
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Indie and Casual with Total Biochem.
Guard the beach, react fast, and save lives using quads, jet skis, motorboats, drones, and a helicopter. Patrol the bay, help those in need and uncover a hidden criminal intrigue beneath the waves.
- 5
pWordle
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Indie with Total Biochem.
pWordle is a fun and challenging word puzzle game inspired by the popular game Wordle and is available in multiple languages. With a virtual keyboard, Word of the Day, and Freeplay mode, a jukebox, gallery, players can unlock images and earn Steam achievements while improving their vocabulary.
- 6
Roads of Da Vinci: In Search of Origins
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Casual with Total Biochem.
Travel across Italy, collect artifacts, and uncover the truth about the origins of Roman mythology through ancient temples and ruins.
- 7
Accident
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Indie with Total Biochem.
Become a journalist who researches old car accident cases. Help victims and perform first aid, obtain evidence and reconstruct the events to discover what really happened.
- 8
WikiArena
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Indie with Total Biochem.
The "trivia roguelike" where Wikipedia articles battle it out and you predict the winner! Guess the length and popularity of articles randomly pulled from Wikipedia's daily growing archive of 6.5+ million entries! Featuring arena, endless and a WikiBot duel mode, no two runs will ever be the same!
- 9
Total Synthesis
Single-player alternative to Total Biochem — playable solo, no multiplayer required. Shares Strategy and Indie with Total Biochem.
The complete organic chemistry study app: 1,000+ practice items, 28 flashcard decks, every mechanism step by step, and full mock exams — built for course exams, MCAT review, and post-bacc refreshers. The bonus: a real deckbuilding roguelike where the chemistry is the combat.