Single-player games like Artificial Extinction
Below are 9 single-player Steam games similar to Artificial Extinction, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Artificial Extinction page.
Ranked picks
- 1

Calyx
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Strategy with Artificial Extinction.
A strategy game with a new kind of enemy, Calyx puts you in charge of a space mining outpost, locked in battle against powerful plant-aliens. Build your base, gather resources, assemble your forces, and take on the Calyx. With only an out-of-date AI for company, can you survive?
- 2

From Glory To Goo
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Strategy with Artificial Extinction.
From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.
- 3

Taur
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Action and Strategy with Artificial Extinction.
Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?
- 4

Machine Mind
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Action and Strategy with Artificial Extinction.
Machine Mind is an action game in a post-apocalyptic setting with elements of survival and RTS. You will fight, craft modules, build your transport, develop and protect your base. You can control other vehicles to automate operations. Discover all the secrets of the destroyed world!
- 5

MarZ: Tactical Base Defense
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Strategy and Indie with Artificial Extinction.
Build your defense base to fight back the undead hordes of Mars and secure the future of the red planet. MarZ is a game of strategy and tactical defense where you must carefully manage your crew and resources as you try to uncover the terrible secrets of the undead.
- 6

Grim Nights
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Strategy and Indie with Artificial Extinction.
Your village must survive for 13 days! Gather resources, expand, explore the underground for riches, and train soldiers to defend against hordes of the undead.
- 7

Infested Planet
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Action and Strategy with Artificial Extinction.
Command a team of 5 elite soldiers against an alien horde of 100,000. Surrounded on all sides, you must outmaneuver and outsmart the enemy.
- 8

Frontline Crisis
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Strategy with Artificial Extinction.
Defend humanity's last hope, pilot a powerful mech, in Frontlines Crisis! A battlefield swarming with insects makes strategic and combat decisions crucial. Each decision will determine your fate. Defend humanity's last sanctuary, fight fiercely, and uphold human honor with wits and courage!
- 9

Artificial Extinction 2
Single-player alternative to Artificial Extinction — playable solo, no multiplayer required. Shares Action with Artificial Extinction.
A Tower Defense hybrid where survival depends on strategy and firepower. Build turrets, mine resources, and hold the line against relentless AI swarms. Switch instantly between commanding the battlefield in RTS view or fighting on the ground in FPS combat.