Single-player games like Cartridge Defense
Below are 10 single-player Steam games similar to Cartridge Defense, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Cartridge Defense page.
Ranked picks
- 1
Zero Division
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
A roguelite deckbuilder crossed with a CCG, set in a dark cyberpunk world. You will lead a three-man squad against competing factions fighting among the ashes of a world-wide war. Each operator comes with a unique deck that can be customized and augmented.
- 2
Kemotaku
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
"Kemotaku" is a brand new roguelike card game mixed with puzzle, deck-building and tower-defence. Beat away attacking enemies and defend your town with a variety of animals!
- 3
Tower Tactics: Liberation
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
We fused deck-building roguelikes and tower defenses in a way never seen before - deploy your towers, collect valuable trinkets and cast powerful spells to defend yourself against the Salkoth!
- 4
For The Warp
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
A roguelike deckbuilding game in space! Explore randomly generated systems, enemies and strange encounters. Build your deck, survive and reach For The Warp gate!
- 5
Power Chord
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
Power Chord is a rock'n roguelite deck-building game. Assemble Earth's mightiest musicians, battle your way through legions of demons, discover new cards to enhance your instruments of destruction, and take back the city, one dive bar at a time.
- 6
Isle of Swaps
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
Grab your cards, it's time to swap! Battle your school pals in this roguelite deckbuilder where you'll trade for new cards when you win defeat them and rip open booster packs looking for rare cards. Conquer everyones dungeon decks to become Critter Champion of the Playground!
- 7
Stellar Orphans
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
"Explore 'Stellar Orphans', a captivating deck-building game where every choice determines the fate of your crew lost in infinite space. Forge alliances, manage resources, and resolve crises to guide your 'Stellar Orphans' to survival. Ready to defy the stars?"
- 8
Overdungeon
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
A completely new style real-time card battle "Overdungeon" Overdungeon combines rogue-like, tower defense and card games. More than 100 cards are Attack, Animal, Building, Spell, Trap, etc..Build your creative and crazy deck!
- 9
Slay the Spire
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Strategy and Indie with Cartridge Defense.
We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!
- 10
Kingdom Run VR
Single-player alternative to Cartridge Defense — playable solo, no multiplayer required. Shares Indie with Cartridge Defense.
Kingdom Run VR is an action-packed fitness game; explore trapped tombs, avoid dangers, collect gems and eliminate enemies!