Single-player games like Plague M.D.
Below are 8 single-player Steam games similar to Plague M.D., ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Plague M.D. page.
Ranked picks
- 1
Apocalipsis
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Apocalipsis is a point-and-click adventure game, in the vain of Samorost and Machinarium, where all puzzles have a hidden meaning. With a unique artstyle inspired by 15th century engravings it tells a story about heartbreak, redemption and, quite literally, the end of the world.
- 2
Death of the Reprobate
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Explore a world built from the luscious landscapes, turbulent townscapes and preposterous portraits of real Renaissance paintings. Death of the Reprobate is a Rabelaisian adventure game from the creator of Four Last Things and The Procession to Calvary.
- 3
Surgeon Simulator
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Simulation with Plague M.D..
Surgeon Simulator is an over-the-top operation sim, stitching together pitch-black humour with life-saving surgery. Become Dr. Burke, a would-be surgeon with a less than conventional toolkit, as he performs procedures on patients including the Heavy from TF2! ...is that a hammer?
- 4
The Procession to Calvary
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Pilfer from pirates, conspire with cardinals and perform miracles with an incompetent magician. The Procession to Calvary is a Pythonesque adventure game made from Renaissance paintings, and a spiritual successor to the critically acclaimed Four Last Things.
- 5
Soul Mates
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
You’re trapped inside a haunted house, stalked by angry ghosts. To survive, you’ll have to run, hide, strategize, give gifts, chat, flirt… Wait, what kind of game is this? Oh right, it’s a point-and-click survival horror dating sim!
- 6
Choice of Life: Middle Ages
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
A card game in a Medieval setting where you make decisions on which not only your life will depend, but also the future of the kingdom!
- 7
Wunderdoktor
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Step into the role of the Wunderdoktor, a traveling doctor whose daily work is to cure rare and exotic diseases. Explore a world full of quackery, ghosts and addictive potions.
- 8
Demetrios - The BIG Cynical Adventure
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
A comedic point-and-click adventure where a hungover antique dealer must solve his own robbery in Paris, dragging himself and his friends into a wildly idiotic journey!