Single-player games like Plague M.D.
Below are 9 single-player Steam games similar to Plague M.D., ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Plague M.D. page.
Ranked picks
- 1
From Lex to Rex
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
A Medieval Gastronomic Adventure! - After years on an empty stomach, Lex decides to become the one who has it all: the Rex. Easier said than done! A hysterical chef, a princess looking for a prince, a strange curse and much more awaits inside the castle. And what´s with the red fruit?
- 2
Pilgrims
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Pilgrims is a playful adventure game, created by the team behind Machinarium and Samorost. Roam the land as you please and make new friends, share a laugh with your fellow travelers and help them complete their little stories, your way. How many different solutions can you find?
- 3
Apocalipsis
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Apocalipsis is a point-and-click adventure game, in the vain of Samorost and Machinarium, where all puzzles have a hidden meaning. With a unique artstyle inspired by 15th century engravings it tells a story about heartbreak, redemption and, quite literally, the end of the world.
- 4
Girlfriend from Hell
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
Manage your strange romance with a demonic girlfriend and experience total chaos! Laugh, be surprised, and unravel absurd situations in this crazy comedic adventure game.
- 5
Goodbye Deponia
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
More chaos, more destruction, more Rufus. Not one, not two, but three Rufuses cause all kinds of crazy mayhem in the long-awaited adventure comedy Goodbye Deponia!
- 6
Mutropolis
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
MUTROPOLIS is a lovely sci-fi adventure set on the abandoned Planet Earth. Play as Henry Dijon (hero, nerd, detective) in search of a legendary lost city. Uncover weird ancient artifacts. And PLEASE don’t get obliterated by an ageless evil. You’ve been warned.
- 7
Puzzle Agent
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Adventure and Casual with Plague M.D..
Created with indie comic artist Graham Annable's unique narrative and visual sensibilities, delivered with the distinctive Telltale storytelling style, Puzzle Agent is sure to challenge, thrill and engage in more ways than you can shake a cryptogram at!
- 8
CHUCHEL
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie and Adventure with Plague M.D..
CHUCHEL is a comedy adventure game from the creators of Machinarium, Botanicula and Samorost. Join the hairy hero Chuchel and his rival Kekel as they will be facing numerous puzzles and challenges in their quest to retrieve the precious cherry!
- 9
Volatica: The Devil's Trap
Single-player alternative to Plague M.D. — playable solo, no multiplayer required. Shares Indie with Plague M.D..
Volatica: The Devil's Trap is a Roguelike Deckbuilder with grim hand-drawn illustrations, dark humor and a branching story. Take on the role of a witch who got trapped by her desires after making a deal with the devil.