Single-player games like Artificial Extinction 2
Below are 8 single-player Steam games similar to Artificial Extinction 2, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Artificial Extinction 2 page.
Ranked picks
- 1

Calyx
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required.
A strategy game with a new kind of enemy, Calyx puts you in charge of a space mining outpost, locked in battle against powerful plant-aliens. Build your base, gather resources, assemble your forces, and take on the Calyx. With only an out-of-date AI for company, can you survive?
- 2

Artificial Extinction
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required. Shares Action with Artificial Extinction 2.
You have 9 days to find a safe place on the planet. Your ship is low on fuel and you have to land. Setup sentry guns around you to defend yourself while you collect more fuel for the ship. AI controlled Drones and Tanks attack you trying to find weaknesses in your defenses.
- 3

X-Morph: Defense
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required. Shares Action with Artificial Extinction 2.
Unique fusion of a top-down shooter and tower defense strategy. You are the invader! Use destructive weapons or lead your enemies into a maze of towers. Strategize in the build mode by carefully selecting various types of alien towers or throw yourself right into the heat of the battle.
- 4

AI War 2
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required.
The most devious and acclaimed artificial intelligence in strategy gaming is better than ever. A grand strategy/RTS hybrid that reverses many conventions of both genres. Take territory without attracting attention, build your empire with care, and adapt to an ever-evolving galactic battleground.
- 5

Welcome Back, Commander
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 6

Acid Planet
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required. Shares Action with Artificial Extinction 2.
Acid Planet is a caustic blend of horde-survival, tower-defense and strategy. Build, fight and evolve to survive against rampaging swarms of monsters and fearsome Kaiju.
- 7

Frontline Crisis
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required.
Defend humanity's last hope, pilot a powerful mech, in Frontlines Crisis! A battlefield swarming with insects makes strategic and combat decisions crucial. Each decision will determine your fate. Defend humanity's last sanctuary, fight fiercely, and uphold human honor with wits and courage!
- 8

From Glory To Goo
Single-player alternative to Artificial Extinction 2 — playable solo, no multiplayer required.
From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.