Single-player games like Microbes and Machines
Below are 12 single-player Steam games similar to Microbes and Machines, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Microbes and Machines page.
Ranked picks
- 1
ARRIVAL: ZERO EARTH
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Fight giant War of the Worlds -style aliens invading Finland during a Winter in the 90's. Build an army of local townspeople in this chaotic semi-autobattler roguelike. Navigate through different biomes to obliterate the aliens from cosmic dimensions.
- 2
REPLIKATOR
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
In this twin stick roguelite shooter, you play as one of the galactic mercenaries, explore a mysterious scientific complex and uncover the secret of the REPLIKATOR project.
- 3
Kitty's Last Adventure
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Cute Survivor where you play as Kitty the cat aboard her flying cat-saucer🛸 created by her distraught human.
- 4
TROUBLE JUICE
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Trouble Juice is a Side Scrolling Shooter Roguelike set in a TV show tournament that is broadcasted across the universe. Use your character's special abilities, and unlock prizes in the Achievement Bingo. Become the ultimate champion and earn your place in the galaxy's hall of fame!
- 5
Woodpunk
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Woodpunk is an exhilarating roguelike bullet hell retro pixel art shooter in a medieval Woodpunk universe, where the primary energy resource is WOOD.
- 6
Run Build Pew!
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
You’re being Bounty-Hunted! Run, Build your ship piece-by-piece and make it work with the parts you find, Destroy outposts and waves of fleets, and Pick your battles carefully to overcome your hunters in this Fast-Paced Top-Down Action Roguelite Shooter.
- 7
NIMRODS
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Assemble a limitless arsenal in this survive-em-up roguelite shooter. As a Gun Manufacturer's testing force, your mission is simple: test the latest gun tech and scavenge alien planets. Collect insane weapon parts to invent crazy guns that slay thousands. You may not survive, but your guns will!
- 8
Void Scrappers
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Blast hordes of alien ships into junk. Collect the scrap to upgrade your ship into an unstoppable force of destruction. Unlock new characters and weapons and upgrade your stats between runs.
- 9
Nuclear Throne
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?
- 10
The Binding of Isaac
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Now 20% More Evil with the Free Halloween update!
- 11
Enter the Gungeon
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Enter the Gungeon is a bullet hell dungeon crawler following a band of misfits seeking to shoot, loot, dodge roll and table-flip their way to personal absolution by reaching the legendary Gungeon’s ultimate treasure: the gun that can kill the past.
- 12
Brave Bubble Heart
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
In Brave Bubble Heart you'll face strange creatures and solve puzzles while saving as many souls as you can that are lost in the abyss. Do not die!