Single-player games like Microbes and Machines
Below are 11 single-player Steam games similar to Microbes and Machines, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Microbes and Machines page.
Ranked picks
- 1
Good Robot
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Good Robot is a fast-paced roguelike shoot-em-up that pits you against thousands of robots out to violate your warranty. Explore a procedurally generated sci-fi metropolis and the depths of corporate depravity, but never stop shooting...unless, of course, you're a Bad Robot. You're not, are you?
- 2
Vampire Survivors
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Mow down thousands of night creatures and survive until dawn! Vampire Survivors is a gothic horror casual game with rogue-lite elements, where your choices can allow you to quickly snowball against the hundreds of monsters that get thrown at you. Be the bullet hell!
- 3
Achilles: Survivor
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Thousands of enemies. One survivor. Fight like a demigod, build deadly defenses, and grow stronger after every run in this fast-paced bullet heaven set in mythic Greece.
- 4
Nuclear Throne
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?
- 5
Hell is Other Demons
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Hell is Other Demons is an action-platform shooter, with Roguelite elements. Explore a sprawling, hand-crafted world full of demons, insanely over-the-top boss fights, and a heavy synthwave soundtrack.
- 6
Atomicrops
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
A twin-stick, bullet-hell, roguelite where you must cultivate and defend the last farm in a post-apocalyptic wasteland. Farm mutated crops, upgrade your weapons, marry townsfolk, and kill every mutant creature that tries to invade your homestead! Yee-haw!
- 7
Ziggurat
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Dungeon-Crawling First Person Shooting at its finest! Fast-paced combat! Dozens of perks, spells and enemies! Level ups! Random Dungeons! Traps! Badass bosses! Carrots!
- 8
REPLIKATOR
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
In this twin stick roguelite shooter, you play as one of the galactic mercenaries, explore a mysterious scientific complex and uncover the secret of the REPLIKATOR project.
- 9
The Binding of Isaac
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Now 20% More Evil with the Free Halloween update!
- 10
Enter the Gungeon
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
Enter the Gungeon is a bullet hell dungeon crawler following a band of misfits seeking to shoot, loot, dodge roll and table-flip their way to personal absolution by reaching the legendary Gungeon’s ultimate treasure: the gun that can kill the past.
- 11
Brave Bubble Heart
Single-player alternative to Microbes and Machines — playable solo, no multiplayer required. Shares Action with Microbes and Machines.
In Brave Bubble Heart you'll face strange creatures and solve puzzles while saving as many souls as you can that are lost in the abyss. Do not die!