Single-player games like Plague Inc: Evolved
Below are 12 single-player Steam games similar to Plague Inc: Evolved, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Plague Inc: Evolved page.
Ranked picks
- 1

Rebel Inc: Escalation
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
A unique and deeply engaging political/military strategic simulation from the creator of Plague Inc. Balance competing civilian and military priorities and deal with a deadly insurgency in order to stabilise a war-torn country.
- 2

War Trains
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
The world as we knew it has been destroyed by the apocalypse... But the railroads have survived the war. And now you need to survive the post-apocalyptic era with their help.
- 3

After Inc: Revival
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
Can you rebuild civilisation after a zombie apocalypse? From the creator of Plague Inc. comes a unique blend of strategic simulation, survival city builder and ‘mini 4X’. Build settlements, harvest resources and shape society as you lead Humanity out of the darkness.
- 4

Bio Inc. Redemption
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
- 5

Corona Simulator
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
"Corona Simulator" is a sophisticated mixture of challenging strategy game and frighteningly detailed virus simulation. As a global pandemic leader, you must skillfully manage nations' resources, make tough decisions, and impose drastic measures to combat the deadly coronavirus.
- 6

Wargame: Airland Battle
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
2 SIDES, 12 NATIONS, 750 UNITS: THE STRATEGY GAME REFERENCE IS BACK! Richer, more beautiful and more accessible, Wargame AirLand Battle is the sequel to the explosive real-time strategy game Wargame European Escalation! 1985.
- 7

Project Zomboid
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Indie and Simulation with Plague Inc: Evolved.
Project Zomboid is the ultimate in zombie survival. Alone or in MP: you loot, build, craft, fight, farm and fish in a struggle to survive. A hardcore RPG skillset, a vast map, massively customisable sandbox and a cute tutorial raccoon await the unwary. So how will you die? All it takes is a bite..
- 8

Cepheus Protocol
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Cepheus Protocol is an Open World RTS Military Survival Game. Play as the CERC hunting Patient 0, maintain Quarantine camps, fight dangerous mutations & Rogue Civilian Combatants . There’s nobody else coming, it’s up to you now.
- 9

Planet Smasher
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Like puzzles? Like explosions? Well then, let's smash some planets together... Play in 2D with keyboard and mouse, or turn it up to eleven and experience full-on planet smashing glory in Virtual Reality with the HTC Vive or Oculus Rift.
- 10

Weedcraft Inc
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Weedcraft Inc explores the business of producing, breeding and selling weed in America, delving deep into the financial, political and cultural aspects of the country's complex relationship with this troublesome and promising plant.
- 11

Pandemic Panic!
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Indie with Plague Inc: Evolved.
We're in lockdown and you're our only hope! Grab your blaster, ready the cure and prepare to face the virus head on in this frantic, wacky and wild hospital. Don't be fooled, this is a task for only the best out there. Think you have what it takes?
- 12

Jurassic World Evolution
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
Place yourself at the heart of the Jurassic franchise and build your own Jurassic World. Bioengineer dinosaurs that think, feel and react intelligently to the world around them and face threats posed by espionage, breakouts and devastating tropical storms in an uncertain world where life always finds a way.