Single-player games like Plague Inc: Evolved
Below are 14 single-player Steam games similar to Plague Inc: Evolved, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Plague Inc: Evolved page.
Ranked picks
- 1
Rebel Inc: Escalation
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
A unique and deeply engaging political/military strategic simulation from the creator of Plague Inc. Balance competing civilian and military priorities and deal with a deadly insurgency in order to stabilise a war-torn country.
- 2
Bio Inc. Redemption
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
- 3
Infectonator 3: Apocalypse
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding.
- 4
DEFCON
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Inspired by the 1983 cult classic film, Wargames, DEFCON superbly evokes the tension, paranoia and suspicion of the Cold War era, playing on the fascinating aspects of psychological gameplay that occur during strategic nuclear warfare.
- 5
911 Operator
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Game about the difficult work of people that manage emergency lines and services. Answer incoming calls and react properly - give first aid instructions, advise, dispatch correct number of firemen / police / ambulances, or sometimes - just ignore the call. Play on ANY CITY in the world!
- 6
The Fabulous Fear Machine
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies.
- 7
Extinction Day
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
End humanity using disasters, plagues, and war. Spread chaos worldwide, combine catastrophic events, and stop them before they escape to the Ark.
- 8
Rebuild 3: Gangs of Deadsville
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Rebuild a ruined city in this post-apocalyptic mix of strategy and simulation. Manage survivors, scavenge for food and supplies, deal with rival gangs, illness, interpersonal strife and zombie attacks.
- 9
Planet Smasher
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Like puzzles? Like explosions? Well then, let's smash some planets together... Play in 2D with keyboard and mouse, or turn it up to eleven and experience full-on planet smashing glory in Virtual Reality with the HTC Vive or Oculus Rift.
- 10
Weedcraft Inc
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Indie with Plague Inc: Evolved.
Weedcraft Inc explores the business of producing, breeding and selling weed in America, delving deep into the financial, political and cultural aspects of the country's complex relationship with this troublesome and promising plant.
- 11
Pandemic Panic!
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Indie with Plague Inc: Evolved.
We're in lockdown and you're our only hope! Grab your blaster, ready the cure and prepare to face the virus head on in this frantic, wacky and wild hospital. Don't be fooled, this is a task for only the best out there. Think you have what it takes?
- 12
Jurassic World Evolution
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
Place yourself at the heart of the Jurassic franchise and build your own Jurassic World. Bioengineer dinosaurs that think, feel and react intelligently to the world around them and face threats posed by espionage, breakouts and devastating tropical storms in an uncertain world where life always finds a way.
- 13
After Inc: Revival
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy and Simulation with Plague Inc: Evolved.
Can you rebuild civilisation after a zombie apocalypse? From the creator of Plague Inc. comes a unique blend of strategic simulation, survival city builder and ‘mini 4X’. Build settlements, harvest resources and shape society as you lead Humanity out of the darkness.
- 14
Plague Inc: The Board Game
Single-player alternative to Plague Inc: Evolved — playable solo, no multiplayer required. Shares Strategy with Plague Inc: Evolved.
Yes, this really is a video game of a board game of a video game! Spread across the world, evolve deadly symptoms and battle rival pathogens to wipe out humanity. An infectious single-player and multiplayer challenge based on the smash hit with over 200 million players.