Single-player games like PATHOGEN X
Below are 17 single-player Steam games similar to PATHOGEN X, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like PATHOGEN X page.
Ranked picks
- 1

Eternal Evil
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
A small town is being taken over by ghouls. Solve puzzles, carefully read notes and use various weapons against horrific and evolving enemies to uncover what is behind this gruesome event. Eternal Evil is an old-school survival-horror game.
- 2

Left 4 Dead 2
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action with PATHOGEN X.
Set in the zombie apocalypse, Left 4 Dead 2 is a co-operative action horror FPS takes you and your friends through the cities, swamps and cemeteries of the Deep South, from Savannah to New Orleans across five expansive campaigns.
- 3

Dead Effect
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
Fight for your life in the INDIE SCI-FI FPS game fit for both casual and hard-core gamers with a passion for hunting down hordes of zombies. Prepare yourselves for the incoming nightmare!
- 4

Resident Evil 4 (2005)
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Adventure with PATHOGEN X.
(Release: 2014) Special agent Leon S. Kennedy is sent on a mission to rescue the U.S. President’s daughter who has been kidnapped.
- 5

Arizona Sunshine®
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
Built exclusively for VR, Arizona Sunshine® puts you and up to 3 fellow survivors in the midst of a zombie apocalypse. Survive solo or in co-op, handle weapons with real-life movements, and explore a post-apocalyptic world in VR. Putting the undead back to rest is more thrilling than ever before.
- 6

Resident Evil Requiem
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Adventure with PATHOGEN X.
Requiem for the dead. Nightmare for the living. Prepare to escape death in a heart-stopping experience that will chill you to your core.
- 7

Nightmare of Decay
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
A first-person action horror game set in a nightmarish manor infested with zombies, psychotic cultists, and a horde of other horrors. Utilize an assortment of different weapons in a brutal fight for survival as you try to escape from the Nightmare of Decay.
- 8

Dementium II HD
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
The visage of doctors and patients alike fade in and out of these nightmarish visions of tortured memories. This eggshell reality is fractured by experiments conducted in the ward. Blood, flesh and screams surround as you put together the pieces of your story and make your escape from the Bright Dawn Treatment Center while the dark...
- 9

Resident Evil
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Adventure with PATHOGEN X.
The game that defined the survival-horror genre is back! Check out the remastered HD version of Resident Evil.
- 10

Quake
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action with PATHOGEN X.
Developed by the award-winning id Software, Quake® is the ground-breaking, original dark fantasy first-person shooter that inspires today’s retro-style FPS games. With Quake (Enhanced), experience the authentic, updated, and visually enhanced version of the original.
- 11

Unreal Tournament: Game of the Year Edition
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action with PATHOGEN X.
Unreal Tournament is the original King of the Hill in the frag-or-be-fragged multiplayer gaming world. As the undisputed 1999 Game of the Year, Unreal Tournament grabbed the first person shooter genre by the soiled seat of its pants and knocked it around the room with its never-before-seen graphics, brutal edge-of-your-seat gameplay and...
- 12

F.E.A.R. 2: Project Origin
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action with PATHOGEN X.
Assume the role of Special Forces Sgt. Becket as your routine mission quickly turns into a fight for survival against the wrath of Alma Wade. As Alma's terrifying power surges out of control, your squad is forced to battle through an apocalyptic landscape in search of clues for how to destroy her!
- 13

Serious Sam 3: BFE
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
Serious Sam 3: BFE is a prequel to the original indie fast action FPS and Game of the Year sensation - Serious Sam: The First Encounter!
- 14

Resident Evil 7 Biohazard
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Adventure with PATHOGEN X.
Fear and isolation seep through the walls of an abandoned southern farmhouse. "7" marks a new beginning for survival horror with the “Isolated View” of the visceral new first-person perspective.
- 15

Resident Evil 2
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action with PATHOGEN X.
A deadly virus engulfs the residents of Raccoon City in September of 1998, plunging the city into chaos as flesh eating zombies roam the streets for survivors. An unparalleled adrenaline rush, gripping storyline, and unimaginable horrors await you. Witness the return of Resident Evil 2.
- 16

VLADiK BRUTAL
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
Fight under the onslaught of mutated monsters, obsessed soldiers and even darker bosses. Just try to survive and find out what to do next in this life, simultaneously tearing your enemies to pieces.
- 17

OPEN DOOR
Single-player alternative to PATHOGEN X — playable solo, no multiplayer required. Shares Action and Indie with PATHOGEN X.
A scientific experiment in which no one survives, in a first-person survival horror game made by one developer In the role of a random person who is trapped in an experiment, try to get out and find out what is happening in this abandoned place.