Single-player games like Clinical Trial
Below are 10 single-player Steam games similar to Clinical Trial, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Clinical Trial page.
Ranked picks
- 1
Drilly Willis
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Drilly Willis has a drill for a head and mad guitar skills. Save music for eternity by fighting your enemies with a one-of-a-kind drillhead weapon, jam songs on your guitar to grant special powers and abilities, and explore an interconnected world of bizarre creatures!
- 2
Lone Chef
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
"Who dares to build on my land?!" The Dark Lord destroyed the restaurant the Chef worked so hard to build... And so begins the Chef's deliciously dramatic quest for revenge! But first... an empty stomach makes for a poor adventure. Better grab something to eat before heading out!
- 3
Cold Lazarus
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Embark on a thrilling odyssey with Lazarus amidst Nimbranumbra's asteroid islands. Encounter charismatic characters, explore ancient ruins, quaint villages, and brave the eerie 'Frameworks.' Battle foes, complete quests, and solve puzzles in this captivating hand-drawn fantasy epic!
- 4
Blast Hopper
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
This adventure pits a lone explorer against the dangers of a strange underground world while blending classic 2D platforming with heart-pounding twin-stick shooting. Embrace the fun and excitement as you jump, shoot, and dash your way through to restore the severed link to the surface
- 5
BioGun
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Get injected into the microscopic world of BioGun. Face viral threats and winding corridors on your mission to save man’s best friend from the inside. Will you save dog-kind from extinction?
- 6
Nocturnal 2
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Ignite your sword and explore the dark depths and towering heights of a forgotten island that consumed itself long ago.
- 7
Caesura
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Adventure with Clinical Trial.
Explore caves, forest, and clouds to discover new secrets in the mysterious world of Caesura. A rhythm driven, hand drawn world. Match your jumps and dashes to the beat to solve challenging puzzles that ask you to dance along with the world as it also dances to the beat.
- 8
Guinea Pig Gunner
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Adventure with Clinical Trial.
Play as a cyborg guinea pig with a teleporter in this run and gun action platformer. Jump, dash, wall climb, and shoot through 12 action packed stages using a massive arsenal and full 360 degree aiming.
- 9
Hollow Knight
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Forge your own path in Hollow Knight! An epic action adventure through a vast ruined kingdom of insects and heroes. Explore twisting caverns, battle tainted creatures and befriend bizarre bugs, all in a classic, hand-drawn 2D style.
- 10
Hollow Knight: Silksong
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Discover a vast, haunted kingdom in Hollow Knight: Silksong! Explore, fight and survive as you ascend to the peak of a land ruled by silk and song.