Single-player games like Clinical Trial
Below are 10 single-player Steam games similar to Clinical Trial, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Clinical Trial page.
Ranked picks
- 1
BioGun
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Get injected into the microscopic world of BioGun. Face viral threats and winding corridors on your mission to save man’s best friend from the inside. Will you save dog-kind from extinction?
- 2
BLADECHIMERA
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Explore a dark and sinister Osaka as the Demon Hunter Shin. Battle demons, regain lost skills, and uncover the truth of your forgotten past in this exciting occult-inspired cyberpunk metroidvania.
- 3
Crypt Custodian
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Adventure with Clinical Trial.
Crypt Custodian is a charming metroidvania about cleaning up the afterlife. Play as Pluto - a mischievous cat who has died, and is sentenced to be the afterworld's janitor... FOREVER! Hang out with other doomed ghosts, battle beasts, and explore a vastly expansive landscape.
- 4
Akatori: Сhapter One
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Join young Mako as she ventures into a wild world of exploration and finds a mysterious bird companion. Navigate through two distinct realms with your staff and face off against an ancient sentinel in this prologue to the action-packed metroidvania Akatori.
- 5
Zexion
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Seek out new weapons and equipment to delve deeper into the dangerous world of Cypher-X72! Be warned, you aren't the only one seeking the forbidden technology known as Zexion! It will take cunning and valor to succeed in this action-packed sci-fi adventure!
- 6
The Mobius Machine
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Discover a vast alien world. Fight the ferocious local fauna and killer machines. Reveal its secrets and find a way to escape. The Mobius Machine is a side-scroller action adventure, with an emphasis on free-form exploration and intense combat.
- 7
Constance
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Constance is a 2D hand-drawn action adventure featuring a paintbrush-wielding artist, striving to escape from a colorful but decaying inner-world, created by her declining mental health.
- 8
Guns of Fury
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Guns of Fury is a retro-inspired action platformer that combines the run & gun and Metroidvania genres. Explore a vast interconnected world, gain new abilities and weapons, battle epic bosses and stop the plans of an evil corporation before it’s too late!
- 9
Hollow Knight
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Forge your own path in Hollow Knight! An epic action adventure through a vast ruined kingdom of insects and heroes. Explore twisting caverns, battle tainted creatures and befriend bizarre bugs, all in a classic, hand-drawn 2D style.
- 10
Hollow Knight: Silksong
Single-player alternative to Clinical Trial — playable solo, no multiplayer required. Shares Action and Indie with Clinical Trial.
Discover a vast, haunted kingdom in Hollow Knight: Silksong! Explore, fight and survive as you ascend to the peak of a land ruled by silk and song.