Single-player games like Escape from Mutation Station
Below are 8 single-player Steam games similar to Escape from Mutation Station, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Escape from Mutation Station page.
Ranked picks
- 1

Dark Trip
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Psychedelic horror escape room where you eat pills and see hallucinations to solve puzzles of an eerie crime case. The most unique and bizarre gaming experiences, where you take on the role of an investigator searching for a missing woman — and are forced to consume drugs during your mission.
- 2

HER TREES : THE PUZZLE HOUSE
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
HER TREES : THE PUZZLE HOUSE is a unique point-and-click puzzle game where you move and combine objects to solve puzzles.Uncover the mysteries of this peculiar room.
- 3

The White Door
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Enter The White Door and discover Rusty Lake’s universe in a new game with a unique style! Explore Robert Hill’s dreams and help him to find his lost memories. Can you survive the strict daily routine and bring back color to Robert's life?
- 4

Mosaic
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Enter a world that’s utterly surreal and eerily familiar. Escape the mundanity of your existence in an experience that will stay with you. Mosaic is a narrative-driven modern adventure game with a story that lasts about 2-3 hours.
- 5

Puzzle Agent
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Created with indie comic artist Graham Annable's unique narrative and visual sensibilities, delivered with the distinctive Telltale storytelling style, Puzzle Agent is sure to challenge, thrill and engage in more ways than you can shake a cryptogram at!
- 6

Puzzle Agent 2
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Agent Nelson Tethers just solved his biggest case yet. So why isn't he satisfied? Venture back to eerie Scoggins, Minnesota to solve the mystery of "the Hidden People" once and for all!
- 7

Rusty Lake: Roots
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
Experience the beginning and end of characters' lives and build your own family tree! Rusty Lake: Roots is the second premium point-and-click adventure by the creators of the Cube Escape series and Rusty Lake Hotel.
- 8

DISTRAINT: Deluxe Edition
Single-player alternative to Escape from Mutation Station — playable solo, no multiplayer required. Shares Adventure with Escape from Mutation Station.
DISTRAINT is a 2D psychological horror adventure game for PC. In order to secure a partnership in a famous company, Price seizes the property of an elderly woman. In that very moment, he finds out the price of his humanity.