Single-player games like Pathologic 3
Below are 14 single-player Steam games similar to Pathologic 3, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Pathologic 3 page.
Ranked picks
- 1
Pathologic 3: Quarantine
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
In this free prologue to a narrative-driven adventure, watch a mysterious plague break out in a small town. Learn what drove a celebrated academic to leave his acclaimed lab. Examine patients, uncover strange secrets, and make first steps towards immortality.
- 2
Pathologic 2
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
Pathologic 2 is a groundbreaking open-world horror RPG. Resist the plague. Make medicine. Heal people. Perform an autopsy. Trade to get what you need. Fight and kill if necessary. Survive. Struggle with an outbreak in a secluded rural town that is rapidly turning into hell.
- 3
Agent of Strange
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
Agent of Strange is a dark role-playing thriller where every mission is a labyrinth of choices and possibilities. You play as a Conspirator who infiltrates a sealed city ruled by the monstrous Family. Overthrow the regime, uncover occult secrets, and shape the City's fate.
- 4
System Says Normal
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
You were hired to watch. Not to ask questions. Night shift. Corporate building. Cameras, reports, anomalies. Your predecessor left no final report. Now you're going to find out why. Please proceed.
- 5
Agent of Strange: Arrival
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
The prologue to Agent of Strange — a dark role-playing thriller where every mission is a labyrinth of choices and possibilities. Start your path as a Conspirator in a desperate struggle against the secret occult regime.
- 6
The Horrorscope: Fatal Awakening
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Simulation and RPG with Pathologic 3.
You will answer a series of questions that will reveal your potential fate. These questions may make you uncomfortable, but with great knowledge comes great sacrifice. Can you make it all the way through The Horrorscope, and if you do, are you sure you want the answers you seek?
- 7
The Alley
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
A first-person psychological horror game. Explore a maze-like alleyway, using your camera to distinguish between supernatural "Ghost Traces" and deceptive "Ghost Feints" while escaping the relentless pursuit of a vengeful ghost.
- 8
Route8
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Simulation with Pathologic 3.
"You're lost on Route 8. You must find a way to escape. This eerie road is terrifying.""Night falls, the phone rings. Who are you? You find yourself driving along Route 8, repeating endlessly."
- 9
Pathologic Classic HD
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
Pathologic Classic HD is the Definitive Edition of the original Cult Classic Psychological First-Person Survival game. In this unforgettable experience, players control one of three unique characters as they try to save a mysterious town from a deadly plague that cannot be stopped.
- 10
Knock-knock
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Adventure with Pathologic 3.
There is an unusual cabin deep in the woods. It had served as a laboratory and a dwelling for three generations of Lodgers.But as of late the latest Lodger has been noticing weird changes in familiar surroundings; things are missing, noises and rattle heard. Something odd is coming out of the woods.
- 11
The Void
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Adventure with Pathologic 3.
Only brought to life by scarce sparks of Color, the bleak, grey Void is a peculiar place. The player gets to explore it, get to know the Sisters, Brothers, and other weird creatures inhabiting it, and learn the ways of Color, harvesting it and drawing sigils that change the world around them.
- 12
Know by heart
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3.
Childhood friends reunite after spending a long time apart, revisiting old memories and rekindling their friendship. However, something beyond their control will ruin this reunion.
- 13
Cargo! The Quest for Gravity
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Adventure and Simulation with Pathologic 3.
Create crazy, yet functional, custom vehicles to solve missions with your own unique style!
- 14
Darkwood 2
Single-player alternative to Pathologic 3 — playable solo, no multiplayer required. Shares Adventure and RPG with Pathologic 3.
Roam freely around the scorched deserts of a dying sea as you secure resources and explore the mysteries of Darkwood. But beware nightfall – seek shelter, shore up your defenses, and pray for the morning light as the horrors of the world hunt the ill-prepared.