Single-player games like Pathologic 3: Quarantine
Below are 14 single-player Steam games similar to Pathologic 3: Quarantine, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Pathologic 3: Quarantine page.
Ranked picks
- 1
Pathologic 3
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
In this psychological horror game, you are a doctor with only 12 days to save a town from a mysterious plague. Make ruthless decisions and diagnose with precision. Shape the town's future and rewrite the past. Hold yourself together while it all falls apart.
- 2
Pathologic 2
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Pathologic 2 is a groundbreaking open-world horror RPG. Resist the plague. Make medicine. Heal people. Perform an autopsy. Trade to get what you need. Fight and kill if necessary. Survive. Struggle with an outbreak in a secluded rural town that is rapidly turning into hell.
- 3
Den-Den: Tokyo Horror
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Den-Den: Tokyo Horror is a J-horror RPG where events unfold in real-time. Survive eight hours in a city where every choice you make impacts the world around you. How many deaths will you be responsible for tonight?
- 4
Void Martyrs
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Adventure and RPG with Pathologic 3: Quarantine.
A grimdark survival horror about a nun in space. Scavenge amongst the drifting space-Basilica, balance your faith with survival, and craft the tools of your salvation.
- 5
VOID CRAWLER
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Void Crawler is a horror game set in a dystopian future, where you pilot a vehicle nicknamed 'The Mole' into a mysterious void deep within the Earth to collect an extremely valuable material for a company dedicated to solving the world's energy crisis.
- 6
Agent of Strange
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Agent of Strange is a dark role-playing thriller where every mission is a labyrinth of choices and possibilities. You play as a Conspirator who infiltrates a sealed city ruled by the monstrous Family. Overthrow the regime, uncover occult secrets, and shape the City's fate.
- 7
Dead Faces
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Dead Faces is a mind bending psychological horror. Unravel Jack's disturbing mind, the faces from his past and the ultimate truth behind his actions. You must remember their faces.
- 8
One Long Night with the Circleheads
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Simulation with Pathologic 3: Quarantine.
The Circleheads are hungry for new souls to join their twisted game. Can you survive the horrors that await?
- 9
Pathologic Classic HD
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Pathologic Classic HD is the Definitive Edition of the original Cult Classic Psychological First-Person Survival game. In this unforgettable experience, players control one of three unique characters as they try to save a mysterious town from a deadly plague that cannot be stopped.
- 10
Knock-knock
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Adventure with Pathologic 3: Quarantine.
There is an unusual cabin deep in the woods. It had served as a laboratory and a dwelling for three generations of Lodgers.But as of late the latest Lodger has been noticing weird changes in familiar surroundings; things are missing, noises and rattle heard. Something odd is coming out of the woods.
- 11
The Void
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Adventure with Pathologic 3: Quarantine.
Only brought to life by scarce sparks of Color, the bleak, grey Void is a peculiar place. The player gets to explore it, get to know the Sisters, Brothers, and other weird creatures inhabiting it, and learn the ways of Color, harvesting it and drawing sigils that change the world around them.
- 12
Know by heart
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Indie and Adventure with Pathologic 3: Quarantine.
Childhood friends reunite after spending a long time apart, revisiting old memories and rekindling their friendship. However, something beyond their control will ruin this reunion.
- 13
Cargo! The Quest for Gravity
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Adventure and Simulation with Pathologic 3: Quarantine.
Create crazy, yet functional, custom vehicles to solve missions with your own unique style!
- 14
Darkwood 2
Single-player alternative to Pathologic 3: Quarantine — playable solo, no multiplayer required. Shares Adventure and RPG with Pathologic 3: Quarantine.
Roam freely around the scorched deserts of a dying sea as you secure resources and explore the mysteries of Darkwood. But beware nightfall – seek shelter, shore up your defenses, and pray for the morning light as the horrors of the world hunt the ill-prepared.