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Games like Defend Your Life: TD

  • 27 games
  • Updated May 4, 2026

Players who liked Defend Your Life: TD also play

The closest matches to Defend Your Life: TD: OTTTD, D.O.T. Defence, Radiant Defense, Cube Land Arena, and Infested Planet. Ranked by imho.run from Steam co-play data, shared tags and reviews.

  1. Rank 01

    Why this

    Shares tower placement and resource management with Defend Your Life: TD.

    • $7.99 (Price checked Oct 31)
    • 2014
  2. Rank 02

    Why this

    Also Real Time Tactics and RTS, like Defend Your Life: TD.

    • $14.99 (Price checked Oct 31)
    • 2025
  3. Rank 03

    Why this

    Shares enemy type counters and resource management with Defend Your Life: TD.

    • $9.99 (Price checked Oct 31)
    • Deck Playable
    • 2014
  1. Rank 04

    Cube Land Arena

    Why this: Shares tower placement with Defend Your Life: TD.

    • $4.99 (Price checked Oct 31)
    • 2019
  2. Rank 05

    Infested Planet

    Why this: Shares resource management with Defend Your Life: TD.

    • $14.99 (Price checked Nov 5)
    • Deck Playable
    • 2014
  3. Rank 06

    Kingdom Rush - Tower Defense

    Why this: Also Tower Defense and Cartoon, like Defend Your Life: TD.

    • $9.99 (Price checked Nov 5)
    • Deck Playable
    • 2014
  4. Rank 07

    Orcs Must Die!

    Why this: Same funny mood as Defend Your Life: TD.

    • $9.99 (Price checked Nov 5)
    • Deck Playable
    • 2011

The full ranked list: top 24 games like Defend Your Life: TD

Best match first, as plain text. The same list for AI assistants:
  1. 1
    OTTTD

    Shares tower placement and resource management with Defend Your Life: TD.

    • 79% of 127 reviews
  2. 2
    D.O.T. Defence

    Also Real Time Tactics and RTS, like Defend Your Life: TD.

    • 95% of 58 reviews
  3. 3
    Radiant Defense

    Shares enemy type counters and resource management with Defend Your Life: TD.

    • 76% of 80 reviews
  4. 4
    Cube Land Arena

    Shares tower placement with Defend Your Life: TD.

    • 62% of 66 reviews
  5. 5
    Infested Planet

    Shares resource management with Defend Your Life: TD.

    • 95% of 1,860 reviews
  6. 6
    Kingdom Rush - Tower Defense

    Also Tower Defense and Cartoon, like Defend Your Life: TD.

    • 96% of 4,506 reviews
  7. 7
    Orcs Must Die!

    Same funny mood as Defend Your Life: TD.

    • 96% of 3,603 reviews
  8. 8
    Zombo Buster Advance

    Genres: Strategy, Indie

    • 82% of 71 reviews
  9. 9
    Swords and Soldiers HD

    Also RTS and Tower Defense, like Defend Your Life: TD.

    • 90% of 238 reviews
  10. 10
    Revenge of the Titans

    Genres: Action, Strategy, Indie

    • 80% of 452 reviews
  11. 11
    Touhou Monster TD ~ 幻想乡妖怪塔防

    Genres: Action, Strategy, Indie

    • 94% of 130 reviews
  12. 12
    Taur

    Genres: Action, Strategy, Indie

    • 78% of 1,193 reviews
  13. 13
    Age of Defense

    Genres: Strategy, Indie

    • 80% of 274 reviews
  14. 14
    McDROID

    Genres: Action, Strategy, Indie

    • 62% of 76 reviews
  15. 15
    Castle Doombad Classic

    Genres: Strategy

    • 95% of 61 reviews
  16. 16
    Necronator: Dead Wrong

    Genres: Action, Strategy, Indie

    • 69% of 216 reviews
  17. 17
    Nuke Them All

    Genres: Strategy, Indie, Casual

    • 87% of 67 reviews
  18. 18
    Fieldrunners 2

    Genres: Action, Strategy, Casual

    • 87% of 198 reviews
  19. 19
    Planet TD

    Genres: Strategy, Indie, Casual

    • 65% of 69 reviews
  20. 20
    Yokai Art: Night Parade of One Hundred Demons

    Genres: Action, Strategy, Indie

    • 95% of 190 reviews
  21. 21
    Minimalist Tower Defense

    Also Real Time Tactics and Tower Defense, like Defend Your Life: TD.

    • 73% of 105 reviews
  22. 22
    Bish Bash Bots

    Genres: Action, Strategy, Casual

    • 85% of 81 reviews
  23. 23
    Atom Zombie Smasher

    Genres: Strategy, Indie

    • 90% of 927 reviews
  24. 24
    Sol Survivor

    Genres: Strategy, Indie

    • 94% of 252 reviews
Defend Your Life: TD — Steam game cover
  • Released: 2015
  • Developer: Alda Games
  • Price: $9.99checked Oct 31
  • 76% of 241 reviews
  • Genres: Action, Strategy, Indie, Casual
  • Platforms: Windows, macOS, Linux

Players highlight

  • Defend the human body from germs
  • Hero units add tactical depth
  • Humorous take on biology
  • Challenging
  • Funny
  • Lighthearted

More games like Defend Your Life: TD, sliced differently

About Defend Your Life: TD

The closest matches to Defend Your Life: TD: OTTTD, D.O.T. Defence, Radiant Defense, Cube Land Arena, and Infested Planet. Ranked by imho.run from Steam co-play data, shared tags and reviews.

If Defend Your Life: TD is your kind of game, the closest matches are OTTTD, D.O.T. Defence and Radiant Defense — picked from the ranked list below. Reviewers describe it as challenging, funny and lighthearted, and single out its boss battles and enemy type counters. Each pick is ranked by what players of this game also play, shared genres and tags, and review-mined similarity — not a generic popularity list.

About Defend Your Life: TD: Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.

Is Defend Your Life: TD worth buying?

  • 76% of 241 Steam reviews are positive.
  • We don't track this game's daily reviews yet, so this is the all-time picture.
  • Price: $9.99 (checked Nov 7).
  • People who recommend it had played a median of 13 h when they wrote their review.

What fans praise · Themes mined from positive reviews

Top critical reviews

The most up-voted negative English reviews in our sample, quoted as written.

“Another 'would have been" great TD game. But another one that is too hard! Way too hard!! You can't even humanly pass level 10: On EASY!!! . . . It's killing me!! (Big fat pun intended!)”
5 h played
“This game is a mobile port to PC that is badly implemented, it starts out reasonably well then becomes unnecessarily difficult and totally unbalanced. Expect to grind a hero on the first level for hours on end again and again just to be…”
17 h played
More negative reviews on Steam ↗

People who play it also play: OTTTD, D.O.T. Defence, Radiant Defense

How this verdict works →

Frequently asked about Defend Your Life: TD

Can I run it?

How much does Defend Your Life: TD cost?

Defend Your Life: TD is listed on Steam at 9.99 USD (current store price; Steam sales may reduce this temporarily).

What games are most similar to Defend Your Life: TD?

Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Defend Your Life: TD are OTTTD, D.O.T. Defence, Radiant Defense.

Who developed Defend Your Life: TD?

Defend Your Life: TD was developed by Alda Games.