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Single-player games like Post Apocalypse Microbe Lab

Below are 12 single-player Steam games similar to Post Apocalypse Microbe Lab, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.

Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Post Apocalypse Microbe Lab page.

Ranked picks

  1. 1
    Fantasy Aquarium — Steam game cover

    Fantasy Aquarium

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    Fantasy Aquarium offers an effortless way to enhance your gaming experience. You can nurture a diverse range of small fish with unique characteristics and construct a vibrant fantasy world from scratch, transforming mundane fish-keeping into an engaging pursuit.

    2024IndieSimulationCasual6.99 USDDeck PlayableSingle-playerSimilar games →
  2. 2
    Cornerpond — Steam game cover

    Cornerpond

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    A chill idle-fishing desktop toy in the corner of your screen. Buy upgrades, catch rare fish, and customize your avatar at your own pace!

    2025IndieSimulationCasual2.99 USDSingle-playerSimilar games →
  3. 3
    Loafing Town — Steam game cover

    Loafing Town

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    A relaxing and humorous idle god simulator that stays at the bottom of your screen or on a second monitor while you do other things. With physics-based dragging interactions, it feels just like playing with desk toys.

    2025IndieSimulationCasual5.59 USDSingle-playerSimilar games →
  4. 4
    Gamblers Table — Steam game cover

    Gamblers Table

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    Gamblers Table is an incremental game where you toss coins to earn money. Buy bigger and better coins, unlock upgrades and hire little helpers to automate the process and take care of all the busy flipping work for you. Simple. Satisfying. Strangely compelling...

    2026StrategyIndieSimulation6.99 USDDeck VerifiedSingle-playerSimilar games →
  5. 5
    Crusaders Quest : Hero Town — Steam game cover

    Crusaders Quest : Hero Town

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie with Post Apocalypse Microbe Lab.

    Welcome to 《Crusader Quest: Hero Town》! A little town inside your PC! Gather heroes and rebuild the town in 《Crusader Quest: Hero Town》, a desktop idle RPG that can be enjoyed even during work hours.

    2026StrategyIndieSimulation6.99 USDDeck PlayableSingle-playerSimilar games →
  6. 6
    Fish to Dish: Idle Sushi — Steam game cover

    Fish to Dish: Idle Sushi

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    Welcome to Fish to Dish: Idle Sushi! This is a relaxing and enjoyable idle fishing game that can sit at the bottom or any corner of your screen, allowing you to enjoy a leisurely sea fishing time in your busy life.

    2025IndieRPGCasual4.79 USDSingle-playerSimilar games →
  7. 7
    Desk Paws — Steam game cover

    Desk Paws

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    Collect over 100 stylish little pets on your desktop! They can freely move along the bottom of your screen, or live in the little houses you've carefully decorated for them. Hmm... or perhaps send them on adventures to earn treats?

    2025IndieSimulationCasual5.99 USDSingle-playerSimilar games →
  8. 8
    Lakeside Bar — Steam game cover

    Lakeside Bar

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required. Shares Indie and Casual with Post Apocalypse Microbe Lab.

    A cozy management sim where the jazz is smooth, the cocktails are cooler than the evening breeze, and the lake reflects your perfect escape.

    2025IndieSimulationCasual2.99 USDDeck PlayableSingle-playerSimilar games →
  9. 9
    Transiruby — Steam game cover

    Transiruby

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required.

    Explore the mysteries of an unknown land! ”Transiruby '' is a metroidvania game where you explore the world as a cyborg protagonist named Siruby. Slash and shoot your way to reveal its hidden secrets!

    2021Action14.99 USDDeck VerifiedSingle-playerSimilar games →
  10. 10
    Fairune Collection — Steam game cover

    Fairune Collection

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required.

    Fairune Collection includes four games in one package – Fairune, Fairune 2, Fairune Origin and Fairune Blast!

    2018AdventureRPG9.99 USDDeck PlayableSingle-playerSimilar games →
  11. 11
    KAMIKO — Steam game cover

    KAMIKO

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required.

    Wield your weapon bestowed by the gods, and open the gates between worlds!

    2019ActionAdventure4.99 USDDeck PlayableSingle-playerSimilar games →
  12. 12
    Picontier / ピコンティア — Steam game cover

    Picontier / ピコンティア

    Single-player alternative to Post Apocalypse Microbe Lab — playable solo, no multiplayer required.

    "Picontier" is a story of mystery and fascinating events that occur on an island as the main character, who awakens from a long sleep on the magical island, resumes life from scratch and meets many intriguing islanders. It is a ‘slow life RPG’ that unravels and reveals surprising twists.

    2022ActionAdventureRPG24.99 USDSingle-playerSimilar games →