Single-player games like Pathogenic
Below are 8 single-player Steam games similar to Pathogenic, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Pathogenic page.
Ranked picks
- 1
SUPER DEBT
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Money is your life in SUPER DEBT! Fight to survive with an arsenal of wildly different weapons and upgrades. In this intense and challenging Twin-Stick Bullet-Hell Roguelike everything costs money, and we mean everything!
- 2
Sundered Soul: Chains of the Undying
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Sundered Soul: Chains of the Undying is a fast-paced twin-stick action roguelite focused on manual aiming, dodging, and skill-based combat. Choose from 9 distinct classes with unique playstyles. Fight to break an eternal curse—where every victory is earned and every mistake is lethal.
- 3
PUNK
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
PUNK is an open world bullet hell action roguelike. Fight vicious creatures, explore diverse biomes, hone your movement skills, manage resources, tinker with weapons and gadgets to upgrade your tiny ship until you become the apex predator of this strange, alien world.
- 4
HyperParasite
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
A rogue-lite twin-stick shooter/brawler that never plays the same twice. Collect and control 60 different characters as the body-snatching alien Parasite with a grudge against humanity. Fight to the top of the food chain: possess the President, push the Big Red Button and one-up the human race.
- 5
Genome Guardian 2
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!
- 6
Mega City Force
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Retrowave Action Roguelike featuring tough agents battling crime to the electrifying music of artists like Droid Bishop, Timecop1983, and more! Choose your agent and dive into hardcore action against enemies and bosses, utilizing a vast arsenal and special abilities that will define your playstyle
- 7
Legend of Dungeon
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Legend of Dungeon is a randomly generated action RPG Beat'em'up with heavy Rogue-like elements, striking visuals, and dynamic music.
- 8
Dungeon Souls
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Dungeon Souls is an action-adventure roguelike dungeon crawler which draws heavy inspiration from Nuclear Throne, Risk of Rain, and Overture. Explore vast procedurally generated dungeons, collect loot, and slay hordes of challenging enemies!