Single-player games like Pathogenic
Below are 8 single-player Steam games similar to Pathogenic, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Pathogenic page.
Ranked picks
- 1
Everything is Crab: The Animal Evolution Roguelite
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
The Animal Evolution Roguelite. Hunt, Flee, Scavenge and Thrive in a living ecosystem. Choose from 125+ Evolutions and Specialisations for unique creature combinations in every run. Adapt to survive the natural curve in order to beat carcinisation... or get Darwin'd trying!
- 2
Enter the Gungeon
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Enter the Gungeon is a bullet hell dungeon crawler following a band of misfits seeking to shoot, loot, dodge roll and table-flip their way to personal absolution by reaching the legendary Gungeon’s ultimate treasure: the gun that can kill the past.
- 3
BlazBlue Entropy Effect
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Enjoy action-packed flashy combat with incredibly satisfying combos and responsive controls! Numerous characters, each with completely unique playstyles and loads of unlockable moves & upgrades! This action roguelike sets the bar for fluid fast-paced action.
- 4
Nuclear Throne
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?
- 5
Identifile: Desktop Dungeon
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Become the ultimate desktop cursor in a deeply infected operating system! Navigate folders like dungeon rooms, delete viruses, and level up with EXEs in this action-packed roguelike.
- 6
Windowkill
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Windowkill is a twin-stick shooter, but the game window itself is constantly closing in on you. Shoot the window edges to push it around your screen as you fight and dodge enemies and bosses in their own windows.
- 7
Ascend to ZERO
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and RPG with Pathogenic.
Have you ever wondered what it feels like to stop time? Ascend to ZERO is a time-bending action-roguelike where you can use your unique ability to freeze time and fight your way to the top.
- 8
Zombie Party
Single-player alternative to Pathogenic — playable solo, no multiplayer required. Shares Action and Indie with Pathogenic.
Zombie Party is a retro rampage of fun and over-the-top action, while still giving the players a deep and engaging Action-RPG Rogue-like experience! Go on a time traveling adventure, or delve deep into procedural dungeons full of gold, loot, and secrets!