IMHO.

Single-player games like Microcosmum: survival of cells

Below are 20 single-player Steam games similar to Microcosmum: survival of cells, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.

Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Microcosmum: survival of cells page.

Ranked picks

  1. 1
    Underwater battles — Steam game cover

    Underwater battles

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    Underwater battles - casual puzzle game made in 2D graphics.

    2022StrategyIndieCasual39.99 USDSingle-playerSimilar games →
  2. 2
    Retailer Tycoon — Steam game cover

    Retailer Tycoon

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    Retailer Tycoon is a base building, retail empire game. This game allows you to create any kind of retail shop you can think of. This RTS game allows you to make billions of in game money from your store. Create endless possibilities of stores and create that chain all though Sydney Australia.

    2021StrategyIndieSimulation4.99 USDSingle-playerSimilar games →
  3. 3
    Idle Game x100 — Steam game cover

    Idle Game x100

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    Idle game for those who tired of boring and infinite idle games

    2022StrategyIndieSimulation0.99 USDDeck PlayableSingle-playerSimilar games →
  4. 4
    The Billion Clicker — Steam game cover

    The Billion Clicker

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    Could you reach the billion? Idle clicker game with simple goals but very addictive gameplay

    2022StrategyIndieSimulation0.99 USDSingle-playerSimilar games →
  5. 5
    VoxFox — Steam game cover

    VoxFox

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    VoxFox - a cute real-time strategy made in voxel graphics for any age.

    2020StrategyIndieSimulation2.99 USDSingle-playerSimilar games →
  6. 6
    Nuclear Sub — Steam game cover

    Nuclear Sub

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    A realistic nuclear submarine simulator will allow you to take command of your crew and battle your fiercest enemies. Arm yourself with missiles, dive into the ocean and fight for your country

    2026ActionStrategyIndieSingle-playerSimilar games →
  7. 7
    Epic Naval Battle Simulator — Steam game cover

    Epic Naval Battle Simulator

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    In Epic Naval Battle Simulator, you are able to create the fleet of your dreams! class from Age of sail, all the way to up modern day! The Yamato class fighting the Bismarck class, the Monitor fighting a Sloop! -Age of sail ships, and iron clads are able to be used atm.-

    2022ActionStrategyIndie1.99 USDSingle-playerSimilar games →
  8. 8
    Machorium -Muscle Aquarium Simulator- — Steam game cover

    Machorium -Muscle Aquarium Simulator-

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Indie and Simulation with Microcosmum: survival of cells.

    Machorium - Muscle Aquarium Simulator - is a relaxing idle and sandbox game where you can unwind and have fun. Use points generated by cute little decorative muscle men to unlock various items and create your ideal muscle aquarium, Machorium.

    2024IndieSimulationCasual7.99 USDDeck PlayableSingle-playerSimilar games →
  9. 9
    Eufloria HD — Steam game cover

    Eufloria HD

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    Experience the celebrated strategy gameplay of Eufloria HD. Conquer asteroids in space and use their resources to grow floral creatures that do your bidding. Expand your empire and fight against several teams of AI opponents that all vie for the same resources and can offer fierce opposition.

    2014StrategyIndie14.99 USDSingle-playerSimilar games →
  10. 10
    SC2VN - The eSports Visual Novel — Steam game cover

    SC2VN - The eSports Visual Novel

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Indie and Simulation with Microcosmum: survival of cells.

    SC2VN is a visual novel about the South Korean StarCraft 2 scene. You play as Mach, a foreign semi-pro trying to make it in eSports who soon learns that success in StarCraft takes more than in-game strategy.

    2015IndieAdventureSimulationFreeDeck PlayableSingle-playerSimilar games →
  11. 11
    守卫魔兽-Guardian of Warcraft — Steam game cover

    守卫魔兽-Guardian of Warcraft

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    This is a summoning tower defense strategy game, with different abilities of monsters and traps, with different effects. the player will continue to upgrade while defending, Become stronger, and summoning more powerful monsters to resist the brave.

    2021ActionStrategyIndie0.99 USDSingle-playerSimilar games →
  12. 12
    Croak Crusader: Spawn of the Spore Spectre — Steam game cover

    Croak Crusader: Spawn of the Spore Spectre

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Indie with Microcosmum: survival of cells.

    Embark on an odyssey into the unknown! Behold the tale of Toadman, an enigmatic being born from alien tech and the mysteries of Radiant Verde. Witness his perilous quest through treacherous jungles to confront Captain Croak in an epic showdown! Welcome to "Spawn of the Spore Spectre"!

    2025ActionIndieAdventureFreeSingle-playerSimilar games →
  13. 13
    Aircraft Evolution — Steam game cover

    Aircraft Evolution

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Indie with Microcosmum: survival of cells.

    Take part in aerial battles with warplanes from different eras — from World War I to the future. Drop bombs, upgrade your aircraft, and turn enemy bases into rubble in the explosive action game Aircraft Evolution!

    2018ActionIndieSimulation8.99 USDDeck PlayableSingle-playerSimilar games →
  14. 14
    STELLATUM — Steam game cover

    STELLATUM

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Indie with Microcosmum: survival of cells.

    Equip your battleship's guns, install faster engines, and increase the power of your reactor. Throw a barrage of rockets on hordes of enemy ships, burning everything in your path!

    2015ActionIndieSimulation2.99 USDSingle-playerSimilar games →
  15. 15
    Microcosmum 2 — Steam game cover

    Microcosmum 2

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    A relaxing strategy game featuring unconventional gameplay. Your objectives include development, evolution, border expansion and protection of your hive.

    2024ActionStrategyIndie15.99 USDDeck PlayableSingle-playerSimilar games →
  16. 16
    Mind Maze — Steam game cover

    Mind Maze

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    MIND MAZE - is a logical competitive game based on capturing of the playing field.

    2017ActionStrategyIndie4.99 USDSingle-playerSimilar games →
  17. 17
    HexLab — Steam game cover

    HexLab

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Strategy and Indie with Microcosmum: survival of cells.

    HexLab is a logical game with a relaxing atmosphere and original gameplay.

    2019StrategyIndieCasual7.99 USDSingle-playerSimilar games →
  18. 18
    Sky of Destruction — Steam game cover

    Sky of Destruction

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Strategy with Microcosmum: survival of cells.

    Sky of Destruction is a top-down shooter created by a team of two people. Combine aircrafts in your combat fleet, which will help you during the mission. Your goal is to destroy the enemy aircraft carrier or buildings, breaking through the enemy air armada. Explosions and total destruction!

    2024ActionStrategyIndie12.99 USDSingle-playerSimilar games →
  19. 19
    Deep, In the  Forest — Steam game cover

    Deep, In the Forest

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Indie with Microcosmum: survival of cells.

    Game is a deck building roguelite card game with RPG elements. Save the forest kingdom from the oppression of the Mad King.

    2020ActionIndieAdventure4.49 USDSingle-playerSimilar games →
  20. 20
    I, AI — Steam game cover

    I, AI

    Single-player alternative to Microcosmum: survival of cells — playable solo, no multiplayer required. Shares Action and Indie with Microcosmum: survival of cells.

    Classic scrolling shooter with modern graphics. You are self-aware AI. You were created on space military station developing weapons. Now your goal is to break out of the lab and win your freedom.

    2020ActionIndieCasual3.99 USDSingle-playerSimilar games →