Single-player games like Antivirus Girl
Below are 9 single-player Steam games similar to Antivirus Girl, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Antivirus Girl page.
Ranked picks
- 1

Cluckmech Oasis
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Action and Strategy with Antivirus Girl.
Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.
- 2

D.O.T. Defence
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Strategy with Antivirus Girl.
Welcome to the frontlines! Build towers, muster armies, and conquer the map. Challenge yourself in the single-player campaign following the Chroma Wars, survive relentless waves in solo defense, or battle it out in local matches against friends and AI bots. Victory comes with the last HQ standing!
- 3

Nunholy
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Action with Antivirus Girl.
In a world overrun by vampires, a group of nuns with their own stories have arrived at the Hunters' Guild. They are ready to wield any power—even that of demons—to defeat their enemies. What fate awaits them on this perilous journey?
- 4

Cavalry Girls
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Strategy and Indie with Antivirus Girl.
In this refreshing and exciting shooting game, lead the brave and fearless girl soldiers to fight with the enemy. Refit different types of machine armour, reasonably deploy machine soldiers with different skills, repel all kinds of enemies, and protect the Empire behind you in the gunfire.
- 5

Touhou Monster TD ~ 幻想乡妖怪塔防
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Action and Strategy with Antivirus Girl.
Easy to learn but hard to master, Touhou Monster TD is a unique Tower defense Game. Control your character, level up and unlock tower skills and character talents, use your wisdom to defeat incoming enemies. Travel the Gensokyo, find out why the “Incident” happened this time.
- 6

Acid Planet
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Action and Strategy with Antivirus Girl.
Acid Planet is a caustic blend of horde-survival, tower-defense and strategy. Build, fight and evolve to survive against rampaging swarms of monsters and fearsome Kaiju.
- 7

Welcome Back, Commander
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Strategy and Simulation with Antivirus Girl.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 8

Frontline Crisis
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Strategy with Antivirus Girl.
Defend humanity's last hope, pilot a powerful mech, in Frontlines Crisis! A battlefield swarming with insects makes strategic and combat decisions crucial. Each decision will determine your fate. Defend humanity's last sanctuary, fight fiercely, and uphold human honor with wits and courage!
- 9

Wedding Witch
Single-player alternative to Antivirus Girl — playable solo, no multiplayer required. Shares Action and Indie with Antivirus Girl.
Here is a witch who wants nothing but to marry you. She decides to seek potions from a certain Succubus in order to charm you... but a labyrinthine forest filled with devils stands in her way. Will she be able to find the potions, and with them, her happy ending?