Single-player games like Bacteria
Below are 13 single-player Steam games similar to Bacteria, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Bacteria page.
Ranked picks
- 1

Splice
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Splice is an experimental and artistic puzzler. Immerse yourself in its microbial world and start splicing! Every level ("strand") consists of a number of cells that you will need to rearrange into a target structure in several moves ("splices").
- 2

Hexcells
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Hexcells is an ambient logic puzzle game for PC, Mac and Linux.
- 3

Logic Bombs
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie with Bacteria.
Welcome to a realm of pure logic, where rules are rules and the next step can always be deduced.
- 4

Unium
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Draw a line. A single line. How complex can that be?
- 5

Strata
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Simple. Elegant. Challenging.
- 6

Waveform
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie with Bacteria.
Navigate the beauty and hazards of the solar system while riding a wave of light through 100+ levels in this innovative action-puzzle game!
- 7

Microcosmum: survival of cells
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie with Bacteria.
Microcosmum: survival of cells. Join the wonderful and amazing world of microorganisms.
- 8

Linelight
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Linelight is an elegant puzzle game set in a world of lines.
- 9

Make it indie!
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie with Bacteria.
Claw your way through the abyss of the mind and survive the horrors that stalk you as you attempt to survive seven days as... an Indie Developer.
- 10

Retention
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
This game is about a person who kept running through his life, never looking back at the past. Once during a trip, he gets into trouble. Now he's lying on the cold ground, buried beneath his bicycle. Slides of various moments fly through his head.
- 11

Energy Balance
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Energy Balance is a number puzzle. You have to swap power units in such a way that their sums form correct chains both vertically and horizontally. The game is easy to learn, but very hard to master. So, are you ready to peep under the hood of an alien spaceship?
- 12

Energy Cycle
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
'Energy Cycle' – new puzzle game from the developers of ‘Energy Balance’. When you click each cell on the game field - it changes color, and the colors of adjacent cells horizontally and vertically. Your task to bring all the cells to the same color. Sounds pretty easy, but try to do it!
- 13

Energy Invasion
Single-player alternative to Bacteria — playable solo, no multiplayer required. Shares Indie and Casual with Bacteria.
Energy Invasion - an arcade game inspired by the classic Breakout. Unlike the original game, your ball does not break blocks on its own, but can launch missiles in a chosen direction.