Single-player games like Quarantine
Below are 14 single-player Steam games similar to Quarantine, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Quarantine page.
Ranked picks
- 1
Plague Inc: Evolved
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
- 2
Wanna Survive
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy with Quarantine.
HIGH SPEED ZOMBIE TACTICS - Fight mobs of undead attacking from all sides in this streamlined turn-based tactics that emphasizes unit placement and synergies. Help the survivors live through fights and manage their rations to avoid permanent death, and they just might be able to reach the Sanctuary.
- 3
Invisible, Inc.
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy with Quarantine.
Take control of Invisible's agents in the field and infiltrate the world's most dangerous corporations. Stealth, precision, and teamwork are essential in high-stakes, high-profit missions, where every move may cost an agent their life.
- 4
Phantom Doctrine
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and RPG with Quarantine.
The year is 1983. The world teeters on the verge of destruction as the Cold War tightens its icy grip. East or West: trust no one, question everything. The fate of humanity rests in your hands as you pit spy versus spy in tactical Phantom Doctrine.
- 5
Xenonauts
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
Xenonauts is a strategy game in which you control a multi-national military organisation defending a Cold War-era Earth from alien invasion, using small squads of persistent soldiers to eliminate the extraterrestrials and recover their technology in turn-based ground combat.
- 6
Frozen Synapse 2
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy with Quarantine.
Frozen Synapse 2 is the sequel to the award-winning turn-based tactical game. Command your squads in a vast procedurally generated city: enter any building, perform any mission, execute any strategy.
- 7
Pandemic: The Board Game
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
Humanity is on the brink of extinction. As members of an elite disease control team, you’re the only thing standing in the way of the four deadly diseases spreading across the world.
- 8
Bio Inc. Redemption
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity?
- 9
Rebel Inc: Escalation
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
A unique and deeply engaging political/military strategic simulation from the creator of Plague Inc. Balance competing civilian and military priorities and deal with a deadly insurgency in order to stabilise a war-torn country.
- 10
My Riding Stables: Life with Horses
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Simulation with Quarantine.
The Riding Stables at Mill Creek are mere ruins, but you are about to change that: stables, riding hall and guesthouse are being renovated and guests will happily pay for their stay...
- 11
Panzer Tactics HD
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Strategy and Simulation with Quarantine.
Strategists to the frontline!The HD remake of the Nintendo DS classic.Are you the strategist that the world has been waiting for?
- 12
Riding Star - Horse Championship!
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Simulation with Quarantine.
Ride like a world champion! Breathtaking action, challenges in show jumping, dressage and cross country riding are waiting for your talent.
- 13
My Best Friends - Cats & Dogs
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Simulation with Quarantine.
You are responsible for the sensitive upbringing of your pet: You decide on the food, the composition of training courses, the grooming and decorating.
- 14
My Vet Practice
Single-player alternative to Quarantine — playable solo, no multiplayer required. Shares Simulation with Quarantine.
Do you sometimes dream of being a vet doctor? Now you can make that dream come true – start your own vet practice!