Single-player games like Guts and Syringes
Below are 9 single-player Steam games similar to Guts and Syringes, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Guts and Syringes page.
Ranked picks
- 1
Octogeddon
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
You ARE Octogeddon, a massive mutant octopus with one mission: DESTROY the world! Grow more tentacles and evolve each of them into deadlier and deadlier weapons until you become the ultimate eight-legged killing machine!
- 2
Kingdom Rush - Tower Defense
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Strategy with Guts and Syringes.
Get ready for an epic journey to defend your kingdom against hordes of orcs, trolls, evil wizards and other nasty fiends using a vast arsenal of towers and spells at your command!Fight on forests, mountains and wastelands, customizing your defensive strategy with different tower upgrades and specializations!
- 3
Yet Another Zombie Defense HD
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Indie with Guts and Syringes.
Top-down zombie shooter with tower defense elements featuring up to 4 players local and online co-op. Build your base by day, defend it by night, put your skills to the test to stay alive as long as possible! Darkness is coming. How long can YOU survive?
- 4
Infested Planet
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
Command a team of 5 elite soldiers against an alien horde of 100,000. Surrounded on all sides, you must outmaneuver and outsmart the enemy.
- 5
Aegis Defenders
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
Take on wild beasts, ruthless soldiers, and ancient gods in this 2D Action-Platformer inspired by Tower-Defense combat.
- 6
Alien Shooter TD
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
Innovative Tower Defense inspired by legendary Alien Shooter series! The game was created in keeping with the best traditions of Sigma`s games, no concessions of any kind - everything is just like in real life!
- 7
Deathtrap
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
Deathtrap is a Tower Defense game with strong action-RPG elements, a game of vicious tricks, killing machines, rotating blades and splattering blood.
- 8
The Culling Of The Cows
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
The Culling Of The Cows is a side-scrolling shooter / tower defence game. You will take the role of Sammy, a soliloquizing schizophrenic farmer with a self prophesied mission to lay waste to the disease spreading over his farm.
- 9
ROD: Revolt Of Defense
Single-player alternative to Guts and Syringes — playable solo, no multiplayer required. Shares Action and Strategy with Guts and Syringes.
Explore a random generated space. Find artifacts and treasure maps. Build and develop your base on a flying platform. Attack or defend against enemies and save the universe!