Single-player games like Protolife
Below are 10 single-player Steam games similar to Protolife, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Protolife page.
Ranked picks
- 1

Revenge of the Titans
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
The ultimate mash-up of Real-time Strategy and Tower Defense!
- 2

Infested Planet
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Command a team of 5 elite soldiers against an alien horde of 100,000. Surrounded on all sides, you must outmaneuver and outsmart the enemy.
- 3

From Glory To Goo
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy with Protolife.
From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.
- 4

Taur
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?
- 5

Creeper World 3: Arc Eternal
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.
- 6

Particle Fleet: Emergence
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Build and design your own fleets and stand opposed to the Particulate in this physics/strategy/RTS/fleet hybrid. Build partially destructible and self repairing ships that interact with enemies less controlled by some scripted logic and more driven by a real time massive physics particle simulation.
- 7

MarZ: Tactical Base Defense
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Build your defense base to fight back the undead hordes of Mars and secure the future of the red planet. MarZ is a game of strategy and tactical defense where you must carefully manage your crew and resources as you try to uncover the terrible secrets of the undead.
- 8

IDUN - Frontline Survival
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
A defense RTS where you can move turrets at will. Extract resources, upgrade technology, and defend against enemy swarms in a gripping space campaign. Hold the line, set up your turrets, and brace for screen-filling hordes!
- 9

Creeper World: Anniversary Edition
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Imagine an enemy that is everywhere and moves like a giant, organic mass across the map. Imagine your base and your people surrounded by a blanket of crushing destruction from all directions. Your only hope, well what hope? Then you take the high ground and pound this enemy into oblivion.
- 10

Hexworld
Single-player alternative to Protolife — playable solo, no multiplayer required. Shares Strategy and Indie with Protolife.
Hexworld is a tactical autobattle RTS where you control the travelling kingdom-island, manage your tiles, collect and upgrade buildings, crash into other islands and watch your rare precious giant golem inevitably fall off the cliff on his way to the front lines.