Single-player games like MOLEK-SYNTEZ
Below are 11 single-player Steam games similar to MOLEK-SYNTEZ, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like MOLEK-SYNTEZ page.
Ranked picks
- 1
Opus Magnum
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Opus Magnum is the latest open-ended puzzle game from Zachtronics, the creators of SpaceChem, Infinifactory, and SHENZHEN I/O. Design and build machines that assemble potions, poisons, and more using the alchemical engineer’s most advanced tool: the transmutation engine!
- 2
SpaceChem
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Zachtronics is back with an ambitious new design-based puzzle game. Take on the role of a Reactor Engineer working for SpaceChem, the leading chemical synthesizer for frontier colonies. Construct elaborate factories to transform raw materials into valuable chemical products!
- 3
SHENZHEN I/O
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
BUILD CIRCUITS. WRITE CODE. RTFM.
- 4
EXAPUNKS
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
The year is 1997. You used to be a hacker, but now you have the phage. You made a deal: one hack, one dose. There’s nothing left to lose… except your life.
- 5
TIS-100
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
TIS-100 is an open-ended programming game by Zachtronics, the creators of SpaceChem and Infinifactory, in which you rewrite corrupted code segments to repair the TIS-100 and unlock its secrets. It’s the assembly language programming game you never asked for!
- 6
Dreamjob: Programmer Simulator - Learn Programming Games
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
A programmer's career sim. Acquire actual coding skills while playing! Learn programming from zero, earn skill points, change your office, create devices and games with visual programming. Our code learning game is a perfect introduction to Python, C++, C#, Java, or JavaScript.
- 7
Comet 64
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Comet 64 is a programming puzzle game. The year is 1984. All you got is a Comet 64 home computer and the operator's manual it came with.
- 8
IT THINKS! - Build Your Own GPU
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Design the chip that powers AI. Start with a single logic gate and build a computer: wire circuits, cast designs into reusable chips, program tiny kernels, and scale your architecture into a working GPU.
- 9
Infinifactory
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Infinifactory is a sandbox puzzle game by Zachtronics, the creators of SpaceChem and Infiniminer. Build factories that assemble products for your alien overlords, and try not to die in the process.
- 10
Last Call BBS
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie and Simulation with MOLEK-SYNTEZ.
Boot up your Z5 Powerlance and dial into Last Call BBS, the last game from Zachtronics! The Barkeep’s loaded up his retro computer with a full set of puzzle games for you to download and play. No need to worry about copy protection, they’re all fully cracked and ready to enjoy!
- 11
Eliza
Single-player alternative to MOLEK-SYNTEZ — playable solo, no multiplayer required. Shares Indie with MOLEK-SYNTEZ.
Eliza is a visual novel about an AI counseling program, the people who develop it, and the people who use it. Follow Evelyn Ishino-Aubrey as she reconnects with people from her past, gets to know the people of Seattle who use Eliza for counseling, and decides the course of her future.