Single-player games like Project Chemistry
Below are 9 single-player Steam games similar to Project Chemistry, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Project Chemistry page.
Ranked picks
- 1

Virtual Chemistry Lab
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
This is a serious game. Made for educational purposes. It was made in order to enable students to understand the high school chemistry curriculum and to provide equality of opportunity.
- 2

Parametric Creature: Lab
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Simulation with Project Chemistry.
Explore and create parametric creatures
- 3

Crispy Circuits
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
Discover the world of electronics by fixing your hamster’s RC plane. Build real circuits, solve increasingly challenging engineering puzzles, and learn how electronic devices actually work. This wholesome circuitry sim lets you electrocute your hamster without authorities getting involved.
- 4

Oil Refinery - The Simulation
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
Operate a fully functional oil refinery! Control distillation, manage pipelines, refine fuels, maintain machinery, and optimize production. Balance efficiency, safety, and profits to expand your refinery and dominate the energy market!
- 5

MythBusters: The Game - Crazy Experiments Simulator
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Simulation with Project Chemistry.
Be a MythBuster in front and behind the camera! The game is a first-person sim that adapts the famous Discovery show. Run crazy experiments and manage the production of episodes.
- 6

Black Hole Simulator
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
A simple black hole simulator.
- 7

Logic World
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
Invent a new computer! Logic World is a first-person sandbox simulation game that's all about digital logic. Play alone or with friends, design unique machines, build up layers of complexity, and experience the joy of circuits!
- 8

while True: learn()
Single-player alternative to Project Chemistry — playable solo, no multiplayer required. Shares Indie and Simulation with Project Chemistry.
You’re a machine learning specialist who makes neural networks but your cat seems to be better at it. Now you must solve puzzles to build a cat-to-human translation system (who knows what else this cat is capable of!). Earn a fortune, buy kickass cat outfits, learn how machine learning really works!
- 9

No Man's Sky
Single-player alternative to Project Chemistry — playable solo, no multiplayer required.
No Man's Sky is a game about exploration and survival in an infinite procedurally generated universe.