Single-player games like SpaceChem
Below are 21 single-player Steam games similar to SpaceChem, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like SpaceChem page.
Ranked picks
- 1
Infinifactory
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Infinifactory is a sandbox puzzle game by Zachtronics, the creators of SpaceChem and Infiniminer. Build factories that assemble products for your alien overlords, and try not to die in the process.
- 2
Opus Magnum
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Opus Magnum is the latest open-ended puzzle game from Zachtronics, the creators of SpaceChem, Infinifactory, and SHENZHEN I/O. Design and build machines that assemble potions, poisons, and more using the alchemical engineer’s most advanced tool: the transmutation engine!
- 3
Charge!
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Charge is a level-based puzzle game where you control the flow of charge around a circuit board. Arrange pre-built components into wondrous machines that take advantage of available resources and design your own modules from scratch.
- 4
SysOps Simulator
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Simulation with SpaceChem.
SysOps Saga is a simulation game that puts you in the shoes of a Site Reliability Engineer (SRE), managing the intricate web of software, security, and hardware to keep digital systems running. Developed by a FAANG veteran, this game offers an immersive and educational experience for IT enthusiasts.
- 5
Comet 64
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Comet 64 is a programming puzzle game. The year is 1984. All you got is a Comet 64 home computer and the operator's manual it came with.
- 6
MOLEK-SYNTEZ
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Use the MOLEK-SYNTEZ to create small molecules with various pharmacological effects from the comfort of your small Romanian apartment.
- 7
TIS-100
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
TIS-100 is an open-ended programming game by Zachtronics, the creators of SpaceChem and Infinifactory, in which you rewrite corrupted code segments to repair the TIS-100 and unlock its secrets. It’s the assembly language programming game you never asked for!
- 8
Quantum Odyssey
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Master the most counter-intuitive logic in existence. Created by the researchers who defined Quantum Literacy, Quantum Odyssey is an open-ended puzzle game where you craft real quantum algorithms. Optimize 500+ challenges, hack other players, and gain insights textbooks can’t provide.
- 9
Baba Is You
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Baba Is You is a puzzle game where the rules you have to follow are present as blocks you can interact with. By manipulating them, you can change how the game works, repurpose things you find in the levels and cause surprising interactions!
- 10
Factorio
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Factorio is a game about building and creating automated factories to produce items of increasing complexity, within an infinite 2D world. Use your imagination to design your factory, combine simple elements into ingenious structures, and finally protect it from the creatures who don't really like you.
- 11
Satisfactory
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Satisfactory is a first-person open-world factory building game with a dash of exploration and combat. Play alone or with friends, explore an alien planet, create multi-story factories, and enter conveyor belt heaven!
- 12
Human Resource Machine
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Program little office workers to solve puzzles. Be a good employee! The machines are coming... for your job. From the creators of World of Goo and Little Inferno.
- 13
The Witness
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
You wake up, alone, on a strange island full of puzzles that will challenge and surprise you.
- 14
FEZ
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Gomez is a 2D creature living in a 2D world. Or is he? When the existence of a mysterious 3rd dimension is revealed to him, Gomez is sent out on a journey that will take him to the very end of time and space. Use your ability to navigate 3D structures from 4 distinct classic 2D perspectives.
- 15
PUSH
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Can you push all the buttons?
- 16
Antichamber
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Antichamber is a mind-bending psychological exploration game where nothing can be taken for granted. Discover an Escher-like world where hallways wrap around upon each other, spaces reconfigure themselves, and accomplishing the impossible may just be the only way forward.
- 17
SHENZHEN I/O
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
BUILD CIRCUITS. WRITE CODE. RTFM.
- 18
EXAPUNKS
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
The year is 1997. You used to be a hacker, but now you have the phage. You made a deal: one hack, one dose. There’s nothing left to lose… except your life.
- 19
Last Call BBS
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie and Simulation with SpaceChem.
Boot up your Z5 Powerlance and dial into Last Call BBS, the last game from Zachtronics! The Barkeep’s loaded up his retro computer with a full set of puzzle games for you to download and play. No need to worry about copy protection, they’re all fully cracked and ready to enjoy!
- 20
Eliza
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
Eliza is a visual novel about an AI counseling program, the people who develop it, and the people who use it. Follow Evelyn Ishino-Aubrey as she reconnects with people from her past, gets to know the people of Seattle who use Eliza for counseling, and decides the course of her future.
- 21
The Zachtronics Solitaire Collection
Single-player alternative to SpaceChem — playable solo, no multiplayer required. Shares Indie with SpaceChem.
The Zachtronics Solitaire Collection is here! Inside you will find all seven Zachtronics solitaire games, updated with new 4K graphics, plus one brand new Tarot-themed solitaire variant only available here.