IMHO.

Games like Chromosome Evil

If Chromosome Evil is your kind of game, the closest matches are Rebirth evolution, Endzone Girls and Surrounded by Death — picked from the ranked list below. Reviewers single out its multiple endings reward replayability, atmospheric and dark. Each pick is ranked by what players of this game also play, shared genres and tags, and review-mined similarity — not a generic popularity list.

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About Chromosome Evil: Dive deep into this Lovecraft-inspired RTS survival. Assemble your team using different classes, skills, and weaponry. It's up to your squad to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?

2022Strategy14.99 USDDeck PlayableWindowsby S.C. 16 BIT NIGHTS S.R.L.
Chromosome Evil — Steam game cover
Players highlight
Cosmic horror atmosphere immerses playersLimited resources force strategic choicesMultiple endings reward replayabilityAtmosphericDarkGrim

Players who liked Chromosome Evil also play

Steam players who put hours into Chromosome Evil also tend to own these titles — a signal called collaborative filtering. imho.run cross-references millions of library ownership patterns to surface games whose real audiences overlap, regardless of whether their genre tags match.

  1. Rebirth evolution

    WHY THIS

    Shares an atmospheric mood with Chromosome Evil.

    Top pick for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    2D pixel style simulation business strategy game Build and operate your own survivor base, recruit and cultivate various professional combatants. Clear zombie strongholds, reduce regional infections, survive in the apocalypse, and establish your own power.

    2023StrategyIndieSimulation8.99 USDSteam ↗
  2. Endzone Girls

    WHY THIS

    Second-strongest match for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    《Endzone Girls》is a Tower Defense Game. You will collect resources and build fortifications before the zombies arrive to kill the zombies that invade your home. In the game, you will unlock different defensive buildings, create a unique style, defend your home in a world full of zombies.

    2025StrategyIndieSimulation7.99 USDSteam ↗
  3. Surrounded by Death

    WHY THIS

    Third-strongest match for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    Lead your people, fight for survival, become their ruler in this 2D strategy game. To accomplish this, you will have to create powerful walls, an efficient economy and a strong army. But it's not enough. Destroy all portals for peace to reign

    2024ActionStrategyAdventure5.99 USDSteam ↗
  4. Zombie Apocalypse - The Last Fortress

    WHY THIS

    Ranked #4 for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    Defend your base against hordes of zombies while using a variety of weapons, vehicles, explosives, soldiers and turrets in this survival tower defense game. Will you be able to create your own strategy and survive for 30 days?

    2023StrategyIndieCasual0.99 USDSteam ↗
  5. Zombie Apocalypse - The Last Defense

    WHY THIS

    Ranked #5 for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    Create your own strategies, tactics and manage your resources in this survival tower defense game. Buy weapons, vehicles, explosives, soldiers, turrets and battle against huge waves of zombies. Can you survive for 25 days?

    2022StrategyIndieCasual0.99 USDSteam ↗
  6. Machinefall

    WHY THIS

    Ranked #6 for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    Machinefall is a post-apocalyptic real time strategy game set on a fully playable global map. Lead humanity’s last survivors as they build bases, gather resources, and wage massive battles against an overwhelming machine swarm. Progress through technological eras from Stone Age to Atomic Age.

    2026StrategySteam ↗
  7. Flesh Eaters

    WHY THIS

    Shares resource management and an atmospheric mood with Chromosome Evil.

    Ranked #7 for Chromosome Evil fans by collaborative filtering across millions of Steam libraries.

    Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead

    2016ActionIndieAdventure4.99 USDSteam ↗
  8. Zombie Commander

    WHY THIS

    Shares a tense mood with Chromosome Evil.

    Ranked #8 for Chromosome Evil fans by collaborative filtering across millions of Steam libraries. Shares Strategy with Chromosome Evil.

    Zombie Commander is a strategy game about bringing the extinction of humanity by a zombies invasion, and lead the apocalpyse !

    2018StrategyFreeDeck PlayableSteam ↗

Cheaper alternatives

Games in the same vein priced at least 40% below Chromosome Evil at current Steam store prices.

  1. Sid Meier's Civilization® V

    WHY THIS

    Priced ~50% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    Create, discover, and download new player-created maps, scenarios, interfaces, and more!

    2010Strategy7.49 USDDeck PlayableSteam ↗
  2. Slay the Spire

    WHY THIS

    Priced ~58% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!

    2019StrategyIndie6.24 USDDeck VerifiedSteam ↗
  3. Inscryption

    WHY THIS

    Priced ~47% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    Inscryption is an inky black card-based odyssey that blends the deckbuilding roguelike, escape-room style puzzles, and psychological horror into a blood-laced smoothie. Darker still are the secrets inscrybed upon the cards...

    2021StrategyIndieAdventure7.99 USDDeck PlayableSteam ↗
  4. Cookie Clicker

    WHY THIS

    Priced ~67% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    An idle game about making cookies! Originally released in 2013 on the web, and actively developed since then. This is the official version for Steam.

    2021StrategyIndieSimulation4.99 USDDeck PlayableSteam ↗
  5. Plants vs. Zombies GOTY Edition

    WHY THIS

    Priced ~67% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    Zombies are invading your home, and the only defense is your arsenal of plants! Armed with an alien nursery-worth of zombie-zapping plants like peashooters and cherry bombs, you'll need to think fast and plant faster to stop dozens of types of zombies dead in their tracks.

    2009Strategy4.99 USDDeck PlayableSteam ↗
  6. Your Only Move Is HUSTLE

    WHY THIS

    Priced ~67% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    Master your technique, execute flashy combos, and outsmart opponents across the world, frame-by-frame. Slow down the clock to fine-tune your fighting style in this innovative, turn-based combat simulator. Pulverize your friends and choreograph spectacular fight scenes. No training mode required.

    2023ActionStrategyIndie4.99 USDDeck PlayableSteam ↗
  7. STAR WARS™ Empire at War - Gold Pack

    WHY THIS

    Priced ~67% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    Command or corrupt an entire galaxy in the definitive Star Wars strategy collection. It is a time of galactic civil war. Will you take up the reins of the Rebellion, assume control of the Empire, or rule the Star Wars Underworld?

    2010Strategy4.99 USDDeck PlayableSteam ↗
  8. Nubby's Number Factory

    WHY THIS

    Priced ~67% under Chromosome Evil on Steam right now. Shares Strategy with Chromosome Evil.

    A plinko-style roguelike where you work at a number factory. Launch your spherical friend, Nubby, down a pegboard to make bigger and bigger numbers! But beware, if you fail to meet your number quota, the sun will explode.

    2025Strategy4.99 USDDeck PlayableSteam ↗

Free alternatives

Free-to-play games that recommended players of this title also tend to enjoy.

  1. Ultimate Custom Night

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Welcome to the ultimate FNAF mashup, featuring 50 selectable characters and custom difficulties!

    2018ActionIndieFree To PlayFreeSteam ↗
  2. missed messages.

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    ‘goth gf’s iPhone’ airdrops you - accept or decline? A love/horror story about life, death, & memes.

    2019IndieSimulationFree To PlayFreeDeck PlayableSteam ↗
  3. Magic Archery

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Train a commoner to become the greatest archer in this short incremental game! Increase your stats, gather wealth from quests, buy upgrades, and infuse your arrows with magic.

    2024IndieSimulationRPGFreeDeck PlayableSteam ↗
  4. Paper Lily - Chapter 1

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Paper Lily is an RPG horror game in which you can solve puzzles in different ways. Explore a hidden world, meet strange characters, and guide Lacie as she attempts to find answers about her unusual condition.

    2024IndieAdventureRPGFreeDeck VerifiedSteam ↗
  5. The Lab

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Welcome to The Lab, a compilation of Valve’s room-scale VR experiments set in a pocket universe within Aperture Science. Fix a robot, defend a castle, adopt a mechanical dog, and more. Still not sold? It’s free!

    2016Free To PlayFreeSteam ↗
  6. Project Kat - Paper Lily Prologue

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Project Kat is a short, unconventional RPG horror game in which there is always another way. Solve puzzles, make friends (or not), and guide Kat as she attempts to uncover the mystery behind a strange golden letter.

    2021IndieAdventureRPGFreeDeck VerifiedSteam ↗
  7. Higurashi When They Cry Hou - Ch.1 Onikakushi

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    Higurashi When They Cry is a sound novel. The music, backgrounds and characters work together to create a world that is the stage of a novel for the user to read. They laugh and cry and get angry. The user takes the point of view of the protagonist to experience the story.

    2015AdventureFreeDeck VerifiedSteam ↗
  8. Cinderella Phenomenon - Otome/Visual Novel

    WHY THIS

    Free-to-play pick from the same recommendation pool — no purchase to try it.

    The Fairytale Curse was only the beginning...

    2017IndieSimulationFree To PlayFreeSteam ↗

More from S.C. 16 BIT NIGHTS S.R.L.

Other recommendable Steam games by S.C. 16 BIT NIGHTS S.R.L., ranked by review count so the studio's hits land first.

  1. Flesh Eaters

    WHY THIS

    Shares resource management and an atmospheric mood with Chromosome Evil.

    Another title from S.C. 16 BIT NIGHTS S.R.L., the studio behind Chromosome Evil.

    Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead

    2016ActionIndieAdventure4.99 USDSteam ↗
  2. Chromosome Evil 2

    WHY THIS

    Shares resource management and an atmospheric mood with Chromosome Evil.

    Another title from S.C. 16 BIT NIGHTS S.R.L., the studio behind Chromosome Evil. Shares Strategy with Chromosome Evil.

    Dive deep into this Lovecraft-inspired RTS survival for a second time. Assemble your strike team and manage your convoy. It's up to you to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?

    2024StrategyRPG19.99 USDDeck PlayableSteam ↗
  3. Welcome Back, Commander

    WHY THIS

    Shares multiple endings, resource management and an atmospheric mood with Chromosome Evil.

    Another title from S.C. 16 BIT NIGHTS S.R.L., the studio behind Chromosome Evil. Shares Strategy with Chromosome Evil.

    Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!

    2025StrategySimulation9.99 USDDeck PlayableSteam ↗
  4. TAURONOS

    WHY THIS

    Shares an atmospheric mood with Chromosome Evil.

    Another title from S.C. 16 BIT NIGHTS S.R.L., the studio behind Chromosome Evil.

    Trapped inside an ancient labyrinth, chased by the mythical Minotaur. Will you reach the center? And if so, what will you discover about yourself there, in the dark?

    2017IndieAdventure4.99 USDDeck PlayableSteam ↗
  5. Desolated District

    WHY THIS

    Another title from S.C. 16 BIT NIGHTS S.R.L., the studio behind Chromosome Evil.

    Desolated District is an Open-World Survival Crafting game set in a post-apocalyptic dystopia. Scavenge for resources, craft essential tools, build your base and battle deadly threats as you explore a sprawling, decaying city inspired by the Kowloon Walled City.

    2025ActionAdventure6.74 USDSteam ↗

Frequently asked about Chromosome Evil

Does Chromosome Evil run on Steam Deck?
Chromosome Evil is rated Playable on Steam Deck — it runs, but expect some manual adjustments (control remapping, text size, or graphics settings) for the best experience.
How much does Chromosome Evil cost?
Chromosome Evil is listed on Steam at 14.99 USD (current store price; Steam sales may reduce this temporarily).
What games are most similar to Chromosome Evil?
Based on Steam play patterns and shared genres/tags, the games most often recommended alongside Chromosome Evil are Rebirth evolution, Endzone Girls, Surrounded by Death.
Who developed Chromosome Evil?
Chromosome Evil was developed by S.C. 16 BIT NIGHTS S.R.L..

imho.run ranks Steam game alternatives using a mix of collaborative filtering (ALS / iALS / EASE / LightGCN), content scoring over genres, categories, Steam tags, developers, and publishers, plus AI-extracted vibes mined from review text. The page above is generated in seed mode anchored on Chromosome Evil.

For library-aware picks tuned to your specific taste, sign in with Steam on the home page.

29 Games Like Chromosome Evil — Ranked for 2026 · imho.run