Single-player games like Chromosome Evil
Below are 12 single-player Steam games similar to Chromosome Evil, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Chromosome Evil page.
Ranked picks
- 1
Chromosome Evil 2
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Dive deep into this Lovecraft-inspired RTS survival for a second time. Assemble your strike team and manage your convoy. It's up to you to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?
- 2
Welcome Back, Commander
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 3
Flesh Eaters
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead
- 4
Last Train Home
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
The Great War is over - the fight continues. Command a legion of soldiers, desperately trying to make their way home amidst the chaos of civil war. Lead them through the unforgiving wilderness onboard an armored train. Manage your crew and resources and try to survive.
- 5
They Are Billions
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
They Are Billions is a Steampunk strategy game set on a post-apocalyptic planet. Build and defend colonies to survive against the billions of the infected that seek to annihilate the few remaining living humans. Can humanity survive after the zombie apocalypse?
- 6
This War of Mine
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
In This War Of Mine you do not play as an elite soldier, rather a group of civilians trying to survive in a besieged city; struggling with lack of food, medicine and constant danger from snipers and hostile scavengers. The game provides an experience of war seen from an entirely new angle.
- 7
Aliens: Dark Descent
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Drop into the gripping journey of Aliens: Dark Descent, a squad-based, single-player action game in the iconic Alien franchise. Lead your soldiers in real-time to stop a new and terrifying kind of Xenomorph outbreak on Planet Lethe.
- 8
Atom Zombie Smasher
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
The zombie apocalypse is upon us and it's up to you to evacuate everyone before they fall prey to the undead. Conduct massive rescue operations with a helping hand from snipers, artillery crews, orbital bombardments, and more.
- 9
ZERO Sievert
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Now with over 600,000 copies sold, ZERO Sievert is a tense top-down extraction shooter that challenges you to scavenge a procedurally-generated wasteland, loot gear, and explore what’s left of a devastated world. When the odds are stacked against you, you’ll need to do more than just survive...
- 10
TAURONOS
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Trapped inside an ancient labyrinth, chased by the mythical Minotaur. Will you reach the center? And if so, what will you discover about yourself there, in the dark?
- 11
Desolated District
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Desolated District is an Open-World Survival Crafting game set in a post-apocalyptic dystopia. Scavenge for resources, craft essential tools, build your base and battle deadly threats as you explore a sprawling, decaying city inspired by the Kowloon Walled City.
- 12
TD Fade to Dark
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
A dark Tower Defense and Survival hybrid where your only currency is time, and how you choose to use. Step into the dark forest, build your defenses during the day, explore, and during the night make every second count before the monsters find you.