Single-player games like Chromosome Evil
Below are 13 single-player Steam games similar to Chromosome Evil, ranked by player overlap. Every pick carries Steam's Single-player category, so multiplayer-only titles or always-online games don't sneak in. imho.run pulls the category data from Steam directly — Single-player here matches what the store labels.
Want the full alternatives list (paid + free + Steam Deck + cheaper picks)? See the parent games like Chromosome Evil page.
Ranked picks
- 1
Rebirth evolution
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
2D pixel style simulation business strategy game Build and operate your own survivor base, recruit and cultivate various professional combatants. Clear zombie strongholds, reduce regional infections, survive in the apocalypse, and establish your own power.
- 2
Endzone Girls
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
《Endzone Girls》is a Tower Defense Game. You will collect resources and build fortifications before the zombies arrive to kill the zombies that invade your home. In the game, you will unlock different defensive buildings, create a unique style, defend your home in a world full of zombies.
- 3
Surrounded by Death
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Lead your people, fight for survival, become their ruler in this 2D strategy game. To accomplish this, you will have to create powerful walls, an efficient economy and a strong army. But it's not enough. Destroy all portals for peace to reign
- 4
Zombie Apocalypse - The Last Fortress
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Defend your base against hordes of zombies while using a variety of weapons, vehicles, explosives, soldiers and turrets in this survival tower defense game. Will you be able to create your own strategy and survive for 30 days?
- 5
Zombie Apocalypse - The Last Defense
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Create your own strategies, tactics and manage your resources in this survival tower defense game. Buy weapons, vehicles, explosives, soldiers, turrets and battle against huge waves of zombies. Can you survive for 25 days?
- 6
Machinefall
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Machinefall is a post-apocalyptic real time strategy game set on a fully playable global map. Lead humanity’s last survivors as they build bases, gather resources, and wage massive battles against an overwhelming machine swarm. Progress through technological eras from Stone Age to Atomic Age.
- 7
Flesh Eaters
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead
- 8
Zombie Commander
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Zombie Commander is a strategy game about bringing the extinction of humanity by a zombies invasion, and lead the apocalpyse !
- 9
ZERO Sievert
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Now with over 600,000 copies sold, ZERO Sievert is a tense top-down extraction shooter that challenges you to scavenge a procedurally-generated wasteland, loot gear, and explore what’s left of a devastated world. When the odds are stacked against you, you’ll need to do more than just survive...
- 10
Chromosome Evil 2
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Dive deep into this Lovecraft-inspired RTS survival for a second time. Assemble your strike team and manage your convoy. It's up to you to survive the onslaught of nightmares that are surely coming your way. Will you find the source of the darkness?
- 11
Welcome Back, Commander
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required. Shares Strategy with Chromosome Evil.
Commander, your strike team is to dive deep into the contaminated city of Sun Stone and get some answers before the mysterious deadly plague spreads . Good luck Commander!
- 12
TAURONOS
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Trapped inside an ancient labyrinth, chased by the mythical Minotaur. Will you reach the center? And if so, what will you discover about yourself there, in the dark?
- 13
Desolated District
Single-player alternative to Chromosome Evil — playable solo, no multiplayer required.
Desolated District is an Open-World Survival Crafting game set in a post-apocalyptic dystopia. Scavenge for resources, craft essential tools, build your base and battle deadly threats as you explore a sprawling, decaying city inspired by the Kowloon Walled City.